Journal of Pure and Applied MicrobiologyVol. 6 No. 1

Prevalence of Hepatitis C Virus in a Sample of Pregnant Women in Davangere: Survey by Antibody Detection

K.G. Raghu Kumar¹, K.V. Yogeesha Babu¹, N.R. Chandrappa², A.R. Hanumanthappa² and V. Vijayanath³

¹Department of Microbiology, S.S. Institute of Medical Sciences and Research Centre, ‘Jnana Shankara’ NH4 Bypass Road, Davangere - 577 005, India. ²Department of Microbiology, J.J.M Medical College, Davangere - 577 004, India. ³Department of Forensic Medicine & Toxicology, S.S.Institute of Medical Sciences & Research centre, Davangere - 577 005, India.

Received on 24 April 2011 and accepted on 28 June 2011

 

ABSTRACT

Hepatitis C virus(HCV) infection is an emerging world wide public health problem. The predominant transmission route of HCV in children is changing with the mother-to-infant transmission type surpassing that through the transfusion of infected blood / blood products. The rate of mother- to- infant HCV transmission is critical to predicting the burden of HCV infection in future generations. The present study aim to determine the prevalence of HCV in pregnant women in Davangere by antibody detection. Blood samples were taken from 100 pregnant women in the age group 15 to 35 years attending a tertiary care hospital, during the period 2006 to 2007. Detection of antibody to HCV(anti-HCV) in the blood samples was carried out by the Immunochromatographic test and Enzyme Linked ImmunoSorbent Assay(ELISA). Out of 100 pregnant women tested, 4 pregnant women showed to be positive for anti HCVs – 2 each in the age groups 15-25 years (yrs) and 26-35 yrs, which is 3.51% and4.65% respectively. Universal screening for HCV in pregnancy is not justified and that selective screening of high risk categories for HCV infection in pregnancy is rational. Future long term studies are needed to explore the mechanisms of vertical transmission of HCV for implementing manipulative procedures that could influence disease outcome both in the infected mother and the child.

Keywords : Hepatitis C virus, pregnant women, screening, immunochromatography, ELISA, Davangere.