Journal of Pure and Applied MicrobiologyVol. 8 No. Special Edition Nov. 2014

Computational Analysis of Micro RNA based Target Interactions Related to Genome Wide Association Studies of Psoriasis

Harishchander Anandaram1 and Daniel Alex Anand2* 

1Department of Bioinformatics, Sathyabama University, Chennai, India 2Department of Biomedical Engineering, Sathyabama University, Chennai, India.

Received on 06 September 2014 and accepted on 13 October 2014

 

ABSTRACT

Identification of a micro RNA (miRNA) based biomarker with multiple gene targets is a major challenge in the era of post genomics and the ability to apply an accurate computational method leads to the initiation of discovering novel miRNAs. In order to identify a miRNA based target interaction among the genes which are associated in the disease pathology of Psoriasis, we obtained a list of Psoriasis related genes from a database for Genome Wide Association Studies (GWAS) and then we went on to identify the network of miRNAs which are significantly related to the GWAS of Psoriasis. Further, we performed an enrichment analysis for identifying a specific miRNA on the basis of statistical tests to predict the miRNA which has the potential to become a biomarker. Finally we have identified the binding of the selected miRNA with the genes which are associated with Psoriasis. At present we have applied the above mentioned protocol for Psoriasis and in future this protocol can also be applied to other diseases.

Keywords : Biomarker, Pathology and Psoriasis.