Journal of Pure and Applied MicrobiologyVol. 8 No. May 2014 Special Edition

Study of the Effects of Eucalyptus and Lavandula Essences on the Growth of Candida albicans Strains Resistant and Sensitive to Itraconazole in Iran

Leila Fozouni1*, Mansour Bayat1, Shahla Roudbar Mohammadi2 and Mohammad Hassan Shahhosseiny3

1Department of Pathobiology,Faculty of Veterinary Specialized Sciences, Tehran Science and Research Branch ,Islamic Azad University, Tehran,Iran. 2TarbiatModares University ,Tehran, Iran. 3Islamic Azad University,Shahr-e-Qods, Iran.

Received on 28 January 2014 and accepted on 20 March 2014

 

ABSTRACT

As Candida albicans have grown more resistant to anti-fungal agents , and also with respect to the restrictions in treatment of fungal diseases studying combinations such as herbal medicine which could replace them seems essential. The aim of the present study is to investigate the effects of herbal essences of eucalyptus and lavandula on the growth of clinical Candida albicans strains and compare them with those Candida albicans which are resistant and sensitive to itraconazole. The present study has been carried out on over 41 Candida albicans taken from patients suffering from candidiasis. The degree of samples? sensitivity to eucalyptus and lavandula were determined through applying broth microdilution method.In the present study, the MIC of eucalyptus against Candida albicans was determined at 4-1024?l/ml, in which the most growth fluctuations it had were seen in the densities of 64 and 32?l/ml. Also, the MIC of lavandula was determined at 1-256 ?l/ml, and the most fluctuations it had in its growth were in the densities of 32 and 16?l/ml. Eucalyptus and lavandula essences have a very good anti-fungal effect against Candida albicans. In the present study, lavandula essence proved better anti-candidiasis effects while no considerable difference was seen between the strains sensitive and resistant to itraconazole in its MIC. In higher densities, eucalyptus essence prevents strains from growing.

Keywords : Candida albicans, Eucalyptus , Lavandula, Essence, MIC, Itraconazole.