Journal of Pure and Applied MicrobiologyVol. 7 No. Special Edition

The Study on Local Thermo-therapy with CT Measure Temperature: the Pharmacokinetics Study of Iohexolthermosensitive Liposomes During Local Thermotherapy

Zhang Bin-gjie1*, Li Mu1, Gao Jing2, Zeng Yong2, Yu Fei3 and Zhuang Lu-ning3

1Department of Neurosurgery, Tianjin First Central Hospital, Tianjin - 300 192 China. 2Tianjin Institute Pharmaceuticals Research, Tianjin - 300 193, China. 3 School of Chemical Engineering and Technology, Tianjin University,Tianjin - 300 193, China.

Received on 03 March 2013 and accepted on 14 April 2013

 

ABSTRACT

To study on using CT measure temperature during local thermo-therapy, we study the pharmacokinetics of intravenous injecting iohexol thermosensitive in rats. Heating group and non-heating group use C6 Glioma model rats, the heated to 43! and normal temperature?Normal rats are intravenous injected with iohexolstandard product iohexol thermosensitive liposome,the t1/2 of heating group prolongs significantly compared with the non-heating group,AUC increases significantly?The AUC of heating group and non-heating group increases significantly compared with the standard product group, demonstrating that under the same dose condition, compared with iv. standard product, iohexol thermosensitive liposome can prolongs the time of iohexol in blood circulation;The thermosensitive liposome encapsulated with iohexol in C6 Glioma model are release theirs content sharply in heat group when the local tumor is heated.

Keywords : Iohexol; Thermosensitive liposome; Pharmacokinetics, CT, Measure temperature.