Evaluation of a Mucoadhesive Buccal Patch for Delivery of Atenolol : In vitro Screening of Bioadhesion

Navneet Verma*, A.K. Wahi, Anurag Verma, P. Chattopadhayay

College of Pharmacy, Institute of Foreign Trade and Management, Moradabad. India

ABSTRACT

Mucoadhesive buccal patches of Atenolol for local delivery of the drug to the oral cavity were formulated by Solvent casting technique. Different mucoadhesive polymers, namely Polyvinyl alcohol (PVA), Sodium carboxymethyl cellulose (NaCMC) and Chitosan of different grade were incorporated into the patches to modify their mucoadhesive properties as well as the rate of drug release, using glycerol as plasticizer. Different concentrations of polymer were used for the preparation of patches. The patches were evaluated on the basis of their physical characteristics like surface pH, folding endurance, mucoadhesive performance, and release rate. The in-vitro drug release was carried out in Franz diffusion cell, with commercially available dialysis membrane. Formulation P-10 (10 % polyvinyl alcohol, 5 % glycerol and 2 % Atenolol) showed sustained release upto 18 hours and also obeyed Higuchi kinetic release pattern.

Keywords: Mucoadhesive Buccal Patch, Atenolol, Bioadhesion.