ISSN: 0973-7510

E-ISSN: 2581-690X

P.K. Sharma, Neeraj Sharma , A.P. Singh and Nisha Mary Joseph
Kiet School of Pharmacy, Ghaziabad, India.
J Pure Appl Microbiol. 2007;1(1):101-104
© The Author(s). 2007
Received: 10/03/2007 | Accepted: 17/03/2007 | Published: 30/04/2007
Abstract

Carvedilol has a bioavailability of about 25 – 35 % because of extensive first-pass metabolism; to overcome this major drawback of carvedilol buccal film was formulated and evaluated for its weight variation, thickness, drug content, and percentage moisture absorption and percentage moisture loss. An in-vitro release study was designed using semipermeable membrane. Four formulations were prepared using 4% HPMC (CV1), 6% HPMC (CV2), 4%EC+0.05% PVP (CV3) and 6%EC + 0.5% PVP (CV4). The in-vitro release profile for the formulation CV4 which contain 6%EC and 0.5%PVP and 8% EC showed sustain release up to 24 hours in Phosphate buffer pH 6.4 having constant ionic strength (µ=0.5) and constant concentration 0.05 µg/ml and obeyed first order kinetics.

Keywords

Carvedilol Buccal Film, Ethyl cellulose, Polyvinylpyrolidone, Hydroxypropylmethylcellulose

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