With the appearance of microbial organisms resistant to multiple antibiotics, also, increase nosocomial infection, specially by Methicillin Resistant Staphylococcus aureus (MRSA), antibacterial effects of Nanocompositeshave attended by the many researchers in recent years. We report the synthesis of binary Nano-metal oxides such as Ag/ZnONanocompositesalso, Ag and ZnONanocompositesvia novel  methods of thermal decomposition of oxalate precursor. XRD, FTIR, SEM and TEM were used to the thermal spectroscopic, structural, morphological characterization and surface area determination of the product, respectively. Strain of MRSA is prepared from ArdabilMedical University.Bacterial sensitivity to Nanocomposites was specially tested using by disc diffusion test and agar dilution test, and also with MIC, and MBC, against MRSA. The particle size was 12 nm, approximately. We reported that value of MIC Ag/ZnO bear on the MRSA was 8 µg/ml. Albeit, the value of MIC bear on the standard strain of Staphylococcus aureus(ATCC 1113) was 128 µg/ml. It is worthly noting that the value of MBC bear on the MRSA and the standard strain of Staphylococcus aureus were 128 µg/ml and 2048 µg/ml. The evidence was revealed that the antibacterial activity of Ag/ZnO were more vigorous to MRSA.