Visible Spectrophotometric Method for the Determination of a Lipid lowering drug in Pharmaceutical Dosage forms

ISSN: 0973-7510

E-ISSN: 2581-690X

S. Vijaya Saradhi¹ , G. Devala Rao², P. Srinivasu² and B.S.S.Venkatesh²

¹Department of Biotechnology, Koneru Lakshmaiah College of Engineering, Vaddeswaram – 522 502, India.

²K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Vijayawada – 520 010, India.

³P.B. Siddhartha College of Arts and Science, Vijayawada – 520 010, India.

J Pure Appl Microbiol. 2007;1(2):313-315

Received: 20/09/2007 | Accepted: 02/10/2007 | Published: 30/10/2007

Abstract

A simple, sensitive and reproducible spectrophotmetric method is developed for the determination of Atorvastatin calcium in bulk and dosage forms. This method is based on the formation of colour species on binding of Atorvastatin calcium with potassium ferro cyanide and ferric chloride to produce pale green coloured solution (l _max at 425 nm). Results of analysis were validated statistically and by recovery studies. This method is successfully employed for the determination of Atorvastatin calcium in various pharmaceutical preparations.

Keywords

Atorvastatin calcium, Visible Spectrophotometric determination, Beer’s Law

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