To study on using CT measure temperature during local thermo-therapy, we study the pharmacokinetics of intravenous injecting iohexol thermosensitive in rats. Heating group and non-heating group use C6 Glioma model rats, the heated to 43! and normal temperatureÿNormal rats are intravenous injected with iohexolstandard product iohexol thermosensitive liposome,the t1/2 of heating group prolongs significantly compared with the non-heating group,AUC increases significantlyÿThe AUC of heating group and non-heating group increases significantly compared with the standard product group, demonstrating that under the same dose condition, compared with iv. standard product, iohexol thermosensitive liposome can prolongs the time of iohexol in blood circulation;The thermosensitive liposome encapsulated with iohexol in C6 Glioma model are release theirs content sharply in heat group when the local tumor is heated.
Iohexol, Thermosensitive liposome, Pharmacokinetics, CT, Measure temperature
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