ISSN: 0973-7510

E-ISSN: 2581-690X

Zhang Bin-gjie1 , Li Mu1, Gao Jing2, Zeng Yong2, Yu Fei3 and Zhuang Lu-ning3
1Department of Neurosurgery, Tianjin First Central Hospital, Tianjin – 300 192 China.
2Tianjin Institute Pharmaceuticals Research, Tianjin – 300 193, China.
3School of Chemical Engineering and Technology, Tianjin University,Tianjin – 300 193, China.
J Pure Appl Microbiol. 2013;7(Spl. Edn.: April):369-374
© The Author(s). 2013
Received: 03/03/2013 | Accepted: 14/04/2013 | Published: 30/04/2013
Abstract

To study on using CT measure temperature during local thermo-therapy, we study the pharmacokinetics of intravenous injecting iohexol thermosensitive in rats. Heating group and non-heating group use C6 Glioma model rats, the heated to 43! and normal temperatureÿNormal rats are intravenous injected with  iohexolstandard product iohexol thermosensitive liposome,the t1/2 of heating group prolongs significantly compared with the non-heating group,AUC increases significantlyÿThe AUC of heating group  and non-heating group increases significantly compared with the standard product group, demonstrating that under the same dose condition, compared with iv. standard product, iohexol thermosensitive liposome can prolongs the time of iohexol in blood circulation;The thermosensitive liposome  encapsulated with iohexol in C6 Glioma model are release theirs content sharply in heat group when the local tumor is heated.

Keywords

Iohexol, Thermosensitive liposome, Pharmacokinetics, CT, Measure temperature

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