Research Article | Open Access
Shariq Ahmed1, Md. Mobasshir Hassan2, Fatima Khan1 , Asfia Sultan1 and Mohammad Salman Shah3
1Department of Microbiology, Jawaharlal Nehru Medical College & Hospital, Aligarh Muslim University, Uttar Pradesh, India.
2Jawaharlal Nehru Medical College & Hospital, Aligarh Muslim University, Uttar Pradesh, India.
3Department of Community Medicine, Jawaharlal Nehru Medical College & Hospital,
Aligarh Muslim University, Uttar Pradesh, India.
Article Number: 8279 | © The Author(s). 2022
J Pure Appl Microbiol. 2022;16(suppl 1):3155-3167. https://doi.org/10.22207/JPAM.16.SPL1.09
Received: 30 November 2022 | Accepted: 23 December 2022 | Published online: 29 December 2022
Issue online: 30 December 2022
Abstract

Human monkeypox (now termed as the “Mpox”) was considered a geographically isolated disease until recently, but the current spread of the disease over 110 locations around the world has created an environment of fear. This study was thus conducted to evaluate the knowledge and apprehensions about the ongoing outbreak of Monkeypox among the medical students and nursing staff who can be a vital source of dissemination of knowledge to the general population. A semi-structured, self-administered questionnaire, was used in this cross-sectional offline study. The study population comprised Medical undergraduate students and nursing staff of a medical college situated in northern India. A total of 340 participants took part in the study comprising 302(88.8%) medical undergraduates and 38(11.1%) nursing staff. Overall, the knowledge of medical students and nursing staff was unsatisfactory. When the questionnaire data were analyzed only 17.05% of the participants had good knowledge, 20.58% had moderate knowledge and 65.78% had poor knowledge. Overall knowledge about the human monkeypox virus and disease was underwhelming. Medical students and nursing staff can be a vital source of dissemination of knowledge to the general population. In this era of emerging threats; to fill the knowledge gaps of the health care professionals’ strategies like continuing medical education, webinars, seminars, and workshops primarily focussing on better clinical, prevention, and control practices should be conducted frequently.

Keywords

Mpox, Monkeypox Virus, Smallpox, Knowledge, Outbreak, Apprehension

Introduction

Poxviridae have always been significant in human history. One of the scariest of Pox viruses which affected humans was smallpox with a high fatality rate of 3 out of 10. Those who survived usually had scars, which were sometimes severe. Although there are other pox viruses which affect humans but they cause mild illnesses or are limited to hosts other than humans. Recently, Monkeypox (now termed as the “Mpox”), which is primarily a disease of monkeys and other small mammals (like rope and sun squirrels, giant-pouched rats, African dormice) emerged in regions where it was not known before. After recovering from the COVID-19 pandemic, the emergence of Monkeypox was considered a new threat. The swift spread of the disease has caused an alarming situation globally with no certain answers about the severity of illness it may be causing and for the extent of spread.1,2

The Monkeypox virus belongs to the family poxviridae, subfamily Chordopoxvirinae, genus Orthopoxvirus and is an enveloped double-stranded DNA virus3. Although it belongs to the same family as smallpox, the disease. Like other pox viruses, MPXV is brick-shaped, with approximately 200-250 nm size, and is surrounded by a lipoprotein envelope.3-6

The virus was identified in 1958, accidentally in monkeys from lesions of a pox-like disease, and the disease acquired the term monkeypox. In 1970, the first human case of monkeypox was reported from the Democratic Republic of the Congo.3 Human cases are common in Central and West Africa, with a fatality rate of 5-10%.3,4 First outbreak outside Africa was reported in 2003, in the United States, with no case of human-to-human transmission.7,8 In contrast, an outbreak during the same time in the Republic of Congo where human transmission was noted.9 Discrete reports of outbreaks with no significant mortality had been reported in African Countries since then.10 However, since May 2022, many non-endemic states in European countries, the United States, Australia, Asia, and the Middle East reported monkeypox cases which raised the alarm.11

In India, first confirmed case was reported on 14, July 2022 from Kerela. India was the tenth country to report a monkeypox case in Asia and the first in South Asia. India reported five cases form Kerala and six from Delhi making a total of eleven confirmed cases of monkeypox.

Recent experiences of the general population and of the healthcare workers during the COVID-19 pandemic and the lineage of monkeypox to smallpox raised many concerns and fear of a pandemic with severe mortality or morbidity. This study was thus conducted to evaluate the knowledge and apprehensions about the ongoing outbreak of Monkeypox among the medical students and nursing staff who can be a vital source of dissemination of knowledge to the general population.

Materials and Methods

Study design
This cross sectional offline study was done to evaluate the knowledge and assess the apprehension for monkeypox during an outgoing outbreak among the medical undergraduates and the nursing staff at a tertiary care and teaching institution of North India. A semi structured, self administered questionnaire, was used to access the knowledge and apprehension about the monkeypox disease. The questionnaire was validated by face validity and a pilot study on 10% of the sample size. Identity of the respondents was not revealed and confidentiality was maintained throughout the entire process. Ethical clearance was obtained from the Institutional Ethical Committee, JNMCH, AMU.

Participants
The study population comprised of Medical undergraduate students (MBBS students from different phase of their study) and nursing staff of a medical college situated in northern India. A total of 38 responses were recorded from nursing staff and the remaining 302 from MBBS students.

Questionnaire
The questionnaire consisted of 22 questions assessing the knowledge regarding epidemiology, clinical manifestations, management and prevention. These questions consisted of two types of questions i) single correct answer ii) multiple correct answer; for questions that had single correct answer, 1 point was given for a correct response and 0 was given for a wrong response. In multiple correct answer type questions, 2 points were given for all correct responses, 1 point for partially correct response and 0 points were given when all responses were wrong. Using the Bloom’s cut off point, a score between of 0 and 18 was given the category of Low knowledge, score between 19-24 was considered moderate knowledge and a score above 24 was considered high knowledge. Three questions included were for assessing the apprehension and attitude of the participants. Two of these questions were supposed to be rated on on a 5-point Likert scale. Questionnaire was given to the consenting participants in person and 25 minutes were provided to complete it. The mean time for completing the questionnaire was 14 minutes.

Statistical analysis
Data were analysed using MedCalc developed by MedCalc Software (acacialaan 22, 8400 ostend, Belgium). Data were presented as frequency (percentage). [https://www.medcalc.org/calc/diagnostic_test.php]

RESULTS

A total of 340 participants took part in the study comprising 302(88.8%) medical undergraduates and 38(11.1%) nursing staff. Overall, the knowledge of medical students and nursing staff was unsatisfactory; with MBBS students scoring slightly better than the nursing staff. Gross deficiencies in knowledge were seen in some areas like the majority of the participants missed respiratory droplets as a mode of transmission; 45% of the missed lymphadenopathy as the clinical feature of the disease; 40.08% mentioned one skin lesion and one serum sample as the recommended sample to collect in monkeypox; 80.5% considered quarantine of contacts as infection prevention and control measure; 73.2% answered shaking of linen well before washing to remove all viruses when handling used bed linen from monkeypox patient as correct option; 35.2% thought that monkeypox patient is infectious till it feels well. (Table 1)

Table (1):
Table 1. Questionnaire with responses and results.

S. No. Question Options Response Percentage
(%)
Response Percentage
(%)
MBBS Percentage
(%)
Nursing Percentage
(%)
1 Monkeypox in humans is an infection with a virus circulating in all wildlife around the world 167 49.11 167 49.11 157 51.98 10 26.31
an infection with a virus circulating in wildlife in Central and West Africa 112 32.94 112 32.94 97 32.11 15 39.47
an infection with bacteria circulating in wildlife in Central and West Africa 23 6.76 23 6.76 10 3.31 13 34.21
none of the above 38 11.17 38 11.17
2 Monkeypox is a zoonosis, which means a disease which can spread
from humans to animals 38 11.17 38 11.17 29 9.6 9 23.68
among animals in zoos 0 0 0 0 0 0 0 0
from animals to humans 302 88.82 302 88.82 273 90.39 29 76.31
3 Monkeypox can be transmitted by: (select all that apply) body fluids 267 78.52 ac237 69.7 231 76.49 6 15.78
lesion material 288 84.7 pc 103 30.29 71 23.5 32 84.21
respiratory droplets 103 30.29
contaminated materials and surfaces 298 87.64
4 What are the main environmental and social factors for monkeypox emergence:
civil unrest and poverty; climate change; expanding mosquito populations; cessation of smallpox vaccination; 14 4.11 14 4.11 5 1.65 9 23.68
deforestation; climate change; civil unrest and poverty; cessation of smallpox vaccination; 174 51.17 174 51.17 158 52.31 16 42.1
cessation of smallpox vaccination; climate change; expanding mosquito populations; overcrowding. 152 44.7 152 44.7 139 46.02 13 34.21
5 Which animals were reported to transmit monkeypox to humans (select all that apply)
Bats 52 15.29 ac 149 43.82 142 47.01 7 18.42
Monkeys 265 77.94 pc 162 47.64 144 47.68 18 47.36
Rodents 212 62.35 aw 29 8.52 16 5.29 13 34.21
Poultry 69 20.29
6 One Health is an approach to developing policies, programmes, legislation, and research for the human-animal-environment interface in which different sectors work together to achieve better public health outcomes
TRUE 289 85 289 85 268 88.74 21 55.26
FALSE 51 15 51 15 34 11.25 17 44.73
7 Monkeypox is characterized by: (select all that apply)
Fever 247 72.64 ac 148 43.52 134 44.37 14 36.84
Cough 148 43.52 pc 192 56.47 168 55.62 24 63.15
Rash 192 56.47
Swollen lymph nodes 187 55
8 How long is the incubation period for human monkeypox?
5 to 13 days 84 24.7 84 24.7 72 12 31.57
3 to 7 days 37 10.88 37 10.88 30  pc 219(64.41) 7 18.42
5 to 21 days 158 46.47 158 46.47 148 aw 121(35.58) 10 26.31
6 to 13 days 61 17.94 61 17.94 52 9 23.68
9 The rash in monkeypox progresses as follows
macule, vesicle, papule, pustule, crust 33 9.7 33 9.7 20 6.62 13 34.21
papule, macule, vesicle, pustule, crust 20 5.88 20 5.88 6 1.98 14 36.84
macule, papule, vesicle, pustule, crust 287 84.41 287 84.41 276 91.39 11 28.94
10 The known complications of monkeypox include? (select all that apply)
secondary bacterial infection 245 72 ac 118 34.7 115 38.07 3 7.89
bleeding 202 59.41 pc

222

65.25 187 61.92 35 92.11
bronchopneumonia 198 58.23
blindness 178 52.35
11 .  Among the following statements, tick those which are correct:
monkeypox and chickenpox both present with a rash on palms and soles 268 78.82 ac 139 40.88 137 45.36 2 5.26
lymphadenopathy is generally present in monkeypox 199 58.52 pc 187 55 164 54.3 23 60.52
Monkeypox rash lesions evolve through the stages of development at the same time 213 62.64 aw 14 4.11 1 0.33 13 34.21
monkeypox rash is usually denser on the extremities than on the trunk 187 55
12 The best diagnostic specimen to collect for laboratory confirmation of monkeypox is:
tonsillar or nasopharyngeal swabs 33 9.7 33 9.7 7 2.31 5 13.15
sputum 20 5.88 20 5.88 4 1.32 2 5.26
skin lesions 287 84.41 287 84.41 285 94.37 24 63.15
serum 10 2.94 10 2.94 3 0.9 7 18.42
13 For laboratory confirmation of monkeypox, it is recommended to collect
a single nasopharyngeal swab 79 23.23 79 23.23 61 20.19 18 47.36
at least two skin lesion samples from different sites of the body 114 33.52 114 33.52 110 36.42 4 10.52
one skin lesion sample and one serum sample 139 40.88 139 40.88 126 41.72 13 34.21
there is no need to collect samples as the clinical picture is sufficient 8 2.35 8 2.35 5 1.65 3 7.89
14 Infection prevention and control precautions for monkeypox include (select all that apply)
use of personal protective equipment (PPE) when caring for patients 257 75.58 ac 68 20 47 15.56 21 55.26
isolation of patients 269 79.11 pc 235 69.11 222 73.5 13 34.21
quarantine of contacts 274 80.58 aw 37 10.88 33 10.92 4 10.52
hand hygiene practices 215 63.23
keeping at least one metre distance 206 60.58
15 What personal protective equipment must be worn when caring for a patient with suspected or confirmed monkeypox or collecting specimens?
gown, gloves 14 4.11 14 4.11 11 3.64 3 7.89
gown, gloves, surgical mask 47 13.82 47 13.82 31 10.26 16 42.1
gown, gloves, surgical mask, goggles 279 82.05 279 82.05 260 86.09 19 50
none of the above 0 0 0 0 0 0 0 0
16 The following are possible long-term sequelae of monkeypox (select all that apply
blindness 288 84.7 ac 138 40.58 132 43.7 6 15.78
paralysis 231 67.94 pc 117 34.41 102 33.77 15 39.47
scarring 309 90.88 aw 85 25 68 22.51 17 44.73
loss of skin pigmentation 214 62.94
17 When handling used bed linen from monkeypox patients we should? (select all that apply)
shake it well before washing to remove all virus particles 249 73.23 ac 118 34.7 98 32.45 20 52.63
store in a leak proof bag 304 89.41 pc 219 64.41 202 66.88 17 44.73
wash separately and at high temperature 268 78.82 aw 3 0.8 2 0.66 1 2.63
wear a medical mask and gloves and a clean gown to protect yourself 254 74.7
18 How should you care for an extensive monkeypox rash?
cover it with a wet towel 0 0 0 0 0 0 0 0
use cloxacillin or amoxicillin 45 13.23 45 13.23 29 9.6 16 42.1
keep it dry and clean; use antibiotics if needed for secondary infection 295 86.76 295 86.76 273 90.39 22 57.89
19 How long is a monkeypox patient infectious?
until antibodies in the blood can be detected 48 14.11 48 14.11 40 13.24 8 21.05
until the crusts fall off and new skin has formed 172 50.58 172 50.58 152 50.33 20 52.63
until the person feels well 120 35.29 120 35.29 110 36.42 10 26.31
20 First case of monkeypox was detected in India in which State?
Kerala 257 75.58 257 75.58 241 79.8 16 42.1
Delhi 35 10.29 35 10.29 32 10.59 3 7.89
Uttar Pradesh 18 5.29 18 5.29 16 5.29 2 5.26
Maharashtra 30 8.82 30 8.82 13 4.3 17 44.73
21 How apprehensive are you of getting monkeypox? 1 (very unconcerned) 58 17.05 58 17.05 50 16.55 8 21.05
2 (unconcerned) 216 63.52 216 63.52 212 70.19 4 10.52
3 (neutral) 31 9.11 31 9.11 19 6.29 12 31.57
4 (concerned) 9 2.64 9 2.64 4 1.32 5 13.15
5 (very concerned) 26 7.64 26 7.64 17 5.62 9 23.68
22 Do you feel we are prepared to tackle monkeypox virus outbreak? Yes 52 15.29 52 15.29 48 15.89 4 10.52
No 288 84.7 288 84.7 254 84.1 34 89.47
23 Can monkeypox outbreak become as severe as Covid-19? 1 (very unlikely) 67 19.7 67 19.7 50 16.55 17 44.73
2 (unlikely) 53 15.58 53 15.58 50 16.55 3 7.89
3 (Neutral) 118 34.7 118 34.7 110 36.42 8 21.05
4 (likely) 34 10 34 10 29 9.6 5 13.15
5 (very likely) 68 20 68 20 63 20.86 5 13.15
24 Antibiotics are required in the management of mild monkeypox infection?
Yes 141 41.47 141 41.47 120 39.73 21 55.26
No 199 58.52 199 58.52 182 60.26 17 44.73
25 Antivirals are required in the management of mild monkeypox infection?
Yes 183 53.82 183 53.82 168 55.62 15 39.47
No 157 46.17 157 46.17 134 44.37 23 60.52

*ac= all correct, pc= partially correct, aw= all wrong

When the questionnaire data were analyzed only 17.05% of the participants had good knowledge, 20.58% had moderate knowledge and 65.78% had poor knowledge. (Table 2)(Figure 1)

Figure 1. Knowledge level of participants

One of the factors which were assessed among the respondents was the apprehension and attitude towards monkeypox disease. 17.5% and 63.52% of respondents very unconcerned and unconcerned about getting monkeypox. Similarly, only 20% and 10% of them believed that its very likely and likely for monkeypox outbreak to become as severe as COVID-19 pandemic. However, majority (84.7%) felt that we are not prepared to tackle monkeypox outbreak (Figure 2).

Figure 2. Participants response to questions regarding the attitude and apprehension towards monkeypox disease

Table (2):
Knowledge levels of participants.

Level of Knowledge
     Score
    Total
n (%age)
Medical undergraduates
n (%age)
Nursing staff
n (%age)
Poor
0-18
212(62.35)
187(61.92)
25(65.78)
Moderate
19-24
70(20.58)
59(19.53)
11(28.94)
Good
>24
58(17.05)
56(18.54)
2(5.26)

n = total responses; %= percentage

DISCUSSION

Emerging and re-emerging pathogens have periodically caused epidemics and pandemics around the globe. The occurrence of these epidemics and pandemics has increased in frequency in recent times. Migrations of population, easy connectivity even to remote areas of the world, and frequent air travel may be responsible for such a phenomenon. As covid-19 pandemic has shown us, the general population, healthcare workers, and the administration all have to face several challenges during such periods. Each new outbreak, epidemic, or pandemic brings new fear and new anxiety. Lack of knowledge and awareness and an indifferent attitude can further worsen the problem. The monkeypox scare just as the covid-19 pandemic was diminishing in severity has questioned our preparedness for such occurrences. Healthcare workers are the best personnel to disseminate such knowledge about the disease in the community.

Assessment of the knowledge and apprehensions about the disease among the budding physicians and their supporting staff (nursing) will help us establish the basis of the measures to be taken to make aware the healthcare personnel and even the general population. In the present study medical undergraduates from different phases of their course and nursing staff answered a questionnaire regarding the monkeypox disease. It was seen that only 17.05% of the participants had good knowledge, whereas 20.58% and 62.35% we’re having moderate knowledge and poor knowledge. Medical undergraduates were slightly better than nursing staff. Similar studies conducted around the world also showed a gap in the knowledge of healthcare professionals and the general population. Harapan et al from Indonesia depicted that only 10.0% of general practitioners had good knowledge (80% Cut-off) which increased to 36.5% when the cut-off was lowered to 70%.12 Ricco et al noted a considerable knowledge gap among Italian physicians.13 Bates et al reported only 48.9% of clinicians from Ohio, USA answered the knowledge questions correctly.14 Studies conducted among the general population in Saudi Arabia 52%15 and university students of UAE 19.9%16 also had poor knowledge of the disease.

India is not endemic to Monkeypox or rather say there was no reported case of monkeypox before the recent outbreak. Therefore, for the healthcare professionals of India, this is a relatively new disease to encounter. Study and research of such uncommon diseases in the country may lack as compared to common/endemic diseases or diseases having global occurrence may be the reason for inadequate knowledge of the participants.

Zoonotic disease means it can spread from animals to humans; Monkeypox caused by Monkeypox virus, an Orthopoxvirus belongs to this category,17 and in the present study 88.8% of the respondents had good awareness of it being a zoonosis. However, only 33.94% of the participants could say that Monkeypox is an infection with virus circulating in the wildlife in Central and West Africa.18 Several factors have been speculated to be the underlying social and environmental factors for the increased frequency of monkeypox outbreaks namely increased susceptibility to monkeypox infection following the cessation of smallpox vaccination, poor countries affected by social unrest leading to dietary changes as consumption of animals as a protein source which are potential MPXV reservoirs, deforestation, easy air travel and increased population density.19 Expanding mosquito population does not affect monkeypox spread as it is not a vector borne disease, however 48.83% of the participants believed it to be as one of the factors facilitating the spread. According to CDC, although animal reservoir is unknown, small mammals (e.g. rope and sun squirrels, giant-pouched rats, African dormice) are thought to maintain the virus in the environments of West and Central Africa and despite its name Monkeys are not the main reservoir.20 Only 8.52% of the current study participants were unaware of monkeys and rodents being the reservoir.

As of 23 Nov 2022 CDC has reported a total of 80,850 cases in 110 location around the word20. A 35 year old man who arrived in Kerala from Middle East was the first case reported from India and the WHO South-East Asia Region.21 Majority (75.58%) of the study participants were aware of the fact. Mode of transmission broadly classified as 1. Animal to human transmission/primary transmission- contact with blood/body fluids, contact with cutaneous/mucosal lesions, bites and scratches, cooking and consumption of infected animals; 2. Human to human transmission/secondary transmission- Direct contact with cutaneous lesions, close contact with recently contaminated object or surfaces, close contact, respiratory droplets.22 Majority (69.7%) of the participants knew the modes of transmission while 30.29 % had some doubt in one or the other documented mode of transmission.

WHO says that the incubation period (interval from infection to onset of symptoms) of monkeypox is usually from 6 to 13 days but can range from 5 to 21 days which 64.41% of the participants correctly answered.23 The course of infection in monkeypox traverse two phases; first being the invasion period (day 1 to day 5) and second by skin eruption period. Invasive period is characterised by fever, headache, chills, myalgia, sore throat and lymphadenopathy. One distinguishing feature of monkeypox is lymphadenopathy usually occurring 1-3 days after the onset of fever that differentiates it from chickenpox, smallpox and measles. The skin eruptions are usually seen from 1-3 days of fever which go through macular, papular, vesicular, and pustular phases.19 In the present study quite low percentage (43.52%) identified all the common sign and symptoms, however most (84.41%) of them were able to tell the correct sequence of progression of rash through different phases. 34.7% of participants correctly identified the majority of commonly occurring complications of monkeypox can include secondary infections, bronchopneumonia, sepsis, encephalitis, and infection of the cornea with ensuing loss of vision.23 Recommended specimen are skin lesion materials like exudates, lesion crusts or swabs from lesion surface20 and a staggering 90.89% of the respondents knew the fact but lacked in knowledge that two swabs from each lesion, preferably from different locations on the body or from lesions that differ in appearance needs to be collected as only 33.52% answered that correctly.20 It was seen that awareness was lacking in knowing the infectivity period of a case of monkeypox which is until the crusts fall off and new skin has formed.20 Participants had a good knowledge of the personal protective equipment to be used when caring for a patient with suspected or confirmed monkeypox or collecting specimens. CDC recommends Gown, Gloves, Eye protection (i.e., goggles or a face shield that covers the front and sides of the face), NIOSH-approved particulate respirator equipped with N95 filters or higher to be worn when entering the patients room.20 However, proper knowledge in infection prevention and control precautions for monkeypox were lacking quite significantly.

When questions regarding attitude and apprehension towards monkeypox was asked majority were unconcerned (63.52%) or very unconcerned (17.05%) about getting monkeypox disease. The reason could be that very few cases (17) of monkeypox has been reported till now with only one death20 which is very less as compared to Covid-19 cases. But the opinion was divided on the question whether Monkeypox outbreak can become as severe as COVID-19 pandemic with neither agreed nor disagreed getting the highest percentage (34.7%). However, a very high percentage agreed that we are still not prepared to tackle monkeypox virus.

Healthcare workers are expected have good knowledge as tend to be involved in publications, read scientific publications, and equip themselves with better knowledge and skills it was found in cases of non-endemic diseases like monkeypox there can be lacunae in the knowledge. Raising awareness, encouraging less risky behaviour and communicating the risk associated with the disease throughout the country particularly areas of high international air travel and areas where recently cases have been recorded is a crucial aspect in controlling or preventing monkeypox spread. Non endemic countries like India should be prepared for outbreaks from exotic pathogens and should device proper surveillance channels and data collection. Enhancing the awareness of health-care workers and even general public should be the first step in preparing for such outbreaks. Knowledge of health care professionals can be amplified by conducting regular seminars, webinars, CMEs on priority basis when such outbreaks are suspected to occur in the country. A multifaceted proactive approach is thus required to fill the gaps in the knowledge of a particular disease which is of utmost importance to fight and control such outbreaks.

The research study has some limitations like being a single centre study and small sample size it soes not reflects the knowledge of whole of India. However, we included budding physicians i.e. medical undergraduates and also nursing staff that play an important role in sample collection, isolation and patient care in India.

CONCLUSION

Overall knowledge about the human monkeypox virus and disease was underwhelming among the medical students and nursing staff. They can be a vital source of dissemination of knowledge to the general population. In this era of emerging threats, to fill the knowledge gaps of the health care professionals’ strategies like continuing medical education, webinars, seminars, and workshops primarily focussing on better clinical, prevention and control practices should be conducted frequently. More emphasis should be paid on non-endemic, emerging and remerging diseases in the medical and its allied sciences curriculum so that they are prepared to tackle these outbreaks, epidemics and pandemics. Similarly, awareness through outreach programmes, electronic and print media should be spread to enhance the knowledge and reduce the apprehensions of the general population.

Declarations

ACKNOWLEDGMENTS
None.

CONFLICT OF INTEREST
The authors declare that there is no conflict of interest.

AUTHORS’ CONTRIBUTION
FK, MMH conceptualized the study. MMH, SA performed data curation. FK, SA, MMS applied methodology. SA investigated the study. MMH performed software analysis. FK, SA, AS wrote the manuscript. AS reviewed and edited the manuscript. MSS performed supervision. All authors read and approved the final manuscript for publication.

FUNDING
None.

DATA AVAILABILITY
All datasets generated or analyzed during this study are included in the manuscript.

ETHICS STATEMENT
This article does not contain any studies with human participants or animals performed by any of the authors.

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