The Expression and Significance Profile of TLR-2 in the Salivary Gland Tumor and Inflammation

ISSN: 0973-7510

E-ISSN: 2581-690X

Meng Yu Sheng^1,3, Yang Hong Yu¹ , Zheng Li Wu², Yang Hui Jun¹, Sheng Shi Yue¹, Yang Yuan Yuan^1,3, Wang Feng^{1, 3} and Ma Ping Ping^{1, 3}

¹Department of Oral & Maxillofacial Surgery, Peking University, Shenzhen Hospital, Shenzhen – 518 036, China.

²Discipline of Oral Diagnosis & Polyclinics, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.

³Medical College of Shantou University, Shantou, China.

J Pure Appl Microbiol. 2013;7(Spl. Edn.: April):33-39

Received: 03/03/2013 | Accepted: 14/04/2013 | Published: 30/04/2013

Abstract

This study was to research the different mRNA and protein expression of Toll-like receptors 2 (TLR-2) characteristics in saliary gland benign (SGBT), malignant tumor tissue (SGMT)and saliary gland inflammation (SGI) by the methods of PCR, qRT-PCR and immunohistochemisty. the results showed that, compared with normal tissues, the TLR-2 mRNA expression in salivary gland benign tumor , salivary gland cancer and inflammation tissues were amount to 6.628 fold , 0.432 fold and 8.583 fold respectively (p <0.05). Importantly, we also found that TLR-2 in these organizations not only has a say in the cytoplasm, and the nucleus has expressed only in the SGMT, which was instant differently previous research. This study suggests that there is an variation of TLR2 association between salivary gland tumor, inflammation and NSG. This finding supports a potential role in tumor development, and provide a foundation for development of immune modulation and chemotherapy for SGT.

Keywords

TLR-2, salivary gland tumor, salivary gland inflammation

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