The Effects on Degradation Treatment of CMC-HLC/EDC-ADH Hydrogels using Collagenase I and Simulated Body Fluid

ISSN: 0973-7510

E-ISSN: 2581-690X

Xian Li¹, Daidi Fan¹ , Jianjun Deng¹, Junfeng Hui¹, Xiaoxuan Ma¹, Chenhui Zhu¹ and Wenjiao Xue²

¹Shaanxi Key Laboratory of Degradable Biomedical Materials, Department of Chemical Engineering, Northwest University, Taibai North Road 229, Xi’an, Shaanxi 710069, China.

²Shaanxi Provincial Institute of Microbiology, No. 76 Xiying Road, Xi’an 710043, China.

J Pure Appl Microbiol. 2013;7(Spl. Edn.: April):475-480

Received: 03/03/2013 | Accepted: 14/04/2013 | Published: 30/04/2013

Abstract

A novel hydrogel for biomedical applications was successfully fabricated by human-like collagen (HLC) and carboxymethylcellulose (CMC) with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and adipic acid dihydrazide (ADH) as cross-linkers. The interior morphologies of these hydrogels were also characterized before and after degradation by collagenase I and simulated body fluid (SBF). The results of in vitro degradability tests of these hydrogels that the CMC-HLC/EDC-ADH hydrogel in SBF indicated that possesses slow degradability than in collagenase I in vitro. Therefore, the results provided the possibility that CMC-HLC/EDC-ADH hydrogels are suitable for biomedical applications such as soft tissue augmentation for their good biocompatibility.

Keywords

Hydrogel, Collagens I and Simulated body fluid

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