ISSN: 0973-7510

E-ISSN: 2581-690X

Xian Li1, Daidi Fan1 , Jianjun Deng1, Junfeng Hui1, Xiaoxuan Ma1, Chenhui Zhu1 and Wenjiao Xue2
1Shaanxi Key Laboratory of Degradable Biomedical Materials, Department of Chemical Engineering, Northwest University, Taibai North Road 229, Xi’an, Shaanxi 710069, China.
2Shaanxi Provincial Institute of Microbiology, No. 76 Xiying Road, Xi’an 710043, China.
J Pure Appl Microbiol. 2013;7(Spl. Edn.: April):475-480
© The Author(s). 2013
Received: 03/03/2013 | Accepted: 14/04/2013 | Published: 30/04/2013

A novel hydrogel for biomedical applications was successfully fabricated by human-like collagen (HLC) and carboxymethylcellulose (CMC) with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and adipic acid dihydrazide (ADH) as cross-linkers. The interior morphologies of these hydrogels were also characterized before and after degradation by collagenase I and simulated body fluid (SBF). The results of in vitro degradability tests of these hydrogels that the CMC-HLC/EDC-ADH hydrogel in SBF indicated that possesses slow degradability than in collagenase I in vitro. Therefore, the results provided the possibility that CMC-HLC/EDC-ADH hydrogels are suitable for biomedical applications such as soft tissue augmentation for their good biocompatibility.


Hydrogel, Collagens I and Simulated body fluid

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© The Author(s) 2013. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.