ISSN: 0973-7510

E-ISSN: 2581-690X

Malak Mohammed Al-Hakeem1, Khalid Khalaf Alharbi2 and Imran Ali Khan2
1Department of Obstetrics and Gynecology,  King Khalid University Hospital,
College of Medicine, King Saud University P.O. Box 60826, Riyadh 11555, Kingdom of Saudi Arabia.
2Department of Clinical Laboratory Sciences, College of Applied Medical Sciences,
King Saud University, Riyadh 11433, Kingdom of Saudi Arabia.
J Pure Appl Microbiol. 2014;8(5):3647-3652
© The Author(s). 2014
Received: 12/08/2014 | Accepted: 17/09/2014 | Published: 31/10/2014
Abstract

Gestational diabetes mellitus (GDM) is a growing health concern that typically appears during the latter half of pregnancy. It is defined as any form of diabetes or glucose intolerance with the onset of or first recognition during pregnancy. Pregnant women with GDM are at risk for certain neonatal complications. Our aim was to investigate the association between the serine/threonine kinase 33 (STK33) rs4929949 polymorphism and the risk of diabetes developed during pregnancy in Saudi women. We genotyped the rs4929949 polymorphism in a hospital-based case-control study, comparing pregnant 200 GDM women with 300 non-GDM women. Genotyping was performed using the TaqMan assay method.  All the glucose values and lipid profiles examined, excluding LDL-C, were associated with an increased risk of GDM (p < 0.05). A significant variation with respect to the genotypic and allele distribution in the disease group was observed when compared to the non-GDM women (OR = 1.83 [95% CI = 1.0, 3.1], p = 0.02) and (OR = 1.33 [95% CI = 1.0, 1.7], p = 0.02). The present study revealed a significant association of the STK33 gene polymorphism with GDM women in a Saudi population.

Keywords

Gestational diabetes, STK33, rs4929949 and Saudi population

Article Metrics

Article View: 839

Share This Article

© The Author(s) 2014. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.