The Association of the Human Leukocyte Antigen (HLA) with the Pathogenesis of Helicobacter pylori

ISSN: 0973-7510

E-ISSN: 2581-690X

The Association of the Human Leukocyte Antigen (HLA) with the Pathogenesis of Helicobacter pylori

R. Azizian^1,2, A. Khosravi³ and Maryam Azizian⁴

¹Research & Developing Center, Mahan Gene Pajoh Co., Tehran, Iran.

²Student Research Committee, Ilam University of medical Sciences, Ilam, Iran.

³Immunology Department, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

⁴Nutrition Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

J Pure Appl Microbiol. 2013;7(3):2183-2189

Received: 18/01/2013 | Accepted: 28/02/2013 | Published: 30/09/2013

Abstract

H. pylori pathogenesis is related to various virulence factor which some of them involved to adhesions. Urease as a main pathogenecity factor to attach to HLA-II is expressed on the surface of Gastric Epithelial Cells (GECs). Apoptosis induced by caspase3 activation as a result of urease effects on Spermine-Spermidine cycle. There is a contribution of HLA-DQA1 gene to the host’s response against H. pylori. HLA allele type as an immune-genetic factors are related to host susceptibility to H. pylori. HLA-DQA1 might be contributed to the susceptibility or resistance to H. pylori infection. Based on the existed evidences the current review aimed to evaluate the results obtained by different studies carried out so far on correlation of human HLA and the pathogenesis of the H. pylori in gastric epithelial cells.

Keywords

Human Leukocyte Antigen, Pathogenesis and Helicobacter pylori

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