This work aimed at synthesis and antimicrobial evaluation of the potency of 2-(2-Nitrovinyl) Furan. The condensation of furfural with nitromethane was conducted in sodium tertiary butoxide. The product’s characterization carried out with ¹H and ¹³C NMR spectrometry and thermal analysis. The 2-(2-Nitrovinyl) Furan was tested with conventional antibiotics (Ridomil plus, Benomyl, Streptomcin, Tetracycline and Amphicillin) against pathogenic bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Salmonella typhimurium) and molds (Fusarium solani and Cercosspora cucurbitarum) and yeast (Candida albicans) by agar well diffusion method. Characterization showed that the reaction product is 2-(2-Nitrovinyl) Furan and the product is crystalline yellow. According to the thermal analysis, the product’s melting point was between 68^oC and 70^oC. The synthesized 2-(2-Nitrovinyl) Furan prevented the growth of the S. typhimurium, C. cucurbitarum, F. solani and C. albicans at 100%, P. aeruginosa and Staph. aureus at 96%, E. coli at 80% inhibition. In contrast, commercial antibiotics produced zones of growth inhibition in the range of 14% to 100%. Therefore, the synthesized 2-(2-Nitrovinyl) Furan appeared to be more powerful antimicrobial than the conventional antibiotics (Ridomil plus, Benomyl, Streptomcin, Tetracycline and Amphicillin).