ISSN: 0973-7510

E-ISSN: 2581-690X

F.K. Mohamed1, A. Y. Soliman1, Ramadan M. Abdel-Motaleb1, Rasha. M. Abdel-Rahman5 , A. M. Abdel-Mohsen2,4, Moustafa M.G. Fouda3,4*, Salem S. Al-Deyab3 and Radim Hrdina5
1Department of Chemistry , Faculty of Science, Fayoum University, Fayoum, Egypt.
2Central European Institute of Technology (CEITEC), Brno University of Technology, Czech Republic.
3Petrochemical Research Chair, Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
4Textile Research Division, National Research Center, Dokki, Giza, P.O. 12622, Giza 12522, Egypt.
5Institute of Organic Chemistry and Technology, University of Pardubice, Czech Republic.
J Pure Appl Microbiol. 2013;7(Spl. Edn.: November):453-458
© The Author(s). 2013
Received: 12/10/2013 | Accepted: 06/11/2013 | Published: 30/11/2013
Abstract

An efficient synthetic method for the preparation of quinoline derivatives started from coumarin compounds was described. Fused coumarin derivative 1 reacted   with amm acetate to afford 3-methylene-quinoline-2, 4-dione 2. In the same way active methylene compounds as ethyl acetoacetate, ethyl cyanoacetate, acetyl acetone and malonitrile reacted with compound 1 and gave the corresponding quinolines derivatives 3-6. All the newly compounds were characterized by elemental analysis, IR and mass spectra.

Keywords

Coumarin, Active methylene, Ammonium acetate, Quinoline, Antibacterial activity

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