ISSN: 0973-7510

E-ISSN: 2581-690X

Sanjay Mohan Shrivastava , Sanjeev Kumar Shukla and Manu Chaudhary
Venus Medicine Research Centre, Hill Top, Industrial Estate, Jharmajri EPIP, Phase I (Extn.) Bhatoli Kalan, Baddi – 173 205, India.
J Pure Appl Microbiol. 2009;3(1):325-330
© The Author(s). 2009
Received: 08/09/2008 | Accepted: 21/11/2008 | Published: 30/04/2009
Abstract

Cefpirome  is a fourth-generation cephalosporins with better broad spectrum activity against gram negative organisms. Sulbactam is a b-lactamase inhibitor similar in structure to clavulanic acid, if sufficient inhibitor is present at the site of infection, the
b-lactamase enzymes should be neutralized and thus the drug used in combination with inhibitor should have an opportunity to inhibit bacterial growth. This study was aimed at evaluating microbial efficacy of  combination in comparison with   Cefpirome and Sulbactam alone. Efficacy was evaluated on the basis Susceptibility analysis, MIC (Minimum Inhibitory Concentration) and Time  Kill Curve analysis in Proteus vulgaris, Pseudomonas aeruginosa, Escherichia coli and Klebsiella  pneumoniae. In all organisms under study, time kill curve analysis demonstrated bacterial maximum killing at  3 hours. In conclusion, Combination of Cefpirome and Sulbactam was found to have more bacterial inhibiting properties than Cefpirome  in  in – vitro  analysis.

Keywords

Cefpirome, Sulbactam, MIC, Time Kill Curve, Anti-Susceptibility Test

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