Cefpirome is a fourth-generation cephalosporins with better broad spectrum activity against gram negative organisms. Sulbactam is a b-lactamase inhibitor similar in structure to clavulanic acid, if sufficient inhibitor is present at the site of infection, the
b-lactamase enzymes should be neutralized and thus the drug used in combination with inhibitor should have an opportunity to inhibit bacterial growth. This study was aimed at evaluating microbial efficacy of combination in comparison with Cefpirome and Sulbactam alone. Efficacy was evaluated on the basis Susceptibility analysis, MIC (Minimum Inhibitory Concentration) and Time Kill Curve analysis in Proteus vulgaris, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae. In all organisms under study, time kill curve analysis demonstrated bacterial maximum killing at 3 hours. In conclusion, Combination of Cefpirome and Sulbactam was found to have more bacterial inhibiting properties than Cefpirome in in – vitro analysis.
Cefpirome, Sulbactam, MIC, Time Kill Curve, Anti-Susceptibility Test
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