ISSN: 0973-7510

E-ISSN: 2581-690X

M.E. Shelke
Department of Chemistry, HVPM College of Engineering and Technology, Amravati 444 606 India.
J Pure Appl Microbiol. 2007;1(2):335-337
© The Author(s). 2007
Received: 15/05/2007 | Accepted: 07/07/2007 | Published: 30/10/2007
Abstract

Novel series of 2-substitutedamino-4-(1-substitutedthiocarbamido-3-yl)-6-substitutedimino-1,3,5-thiadiazines[2a(i) to 2f(iii)] have been obtained by basification of their hydrochloride [1a(1) to 1f(iii)],which are prepared by the interaction of 1,3-Bis-(n- substitutedthioamido) guanidine and substitutedisocyanodichloride. The latter were prepared initially by the condensation of aryl/alkylisothiocyanate and guanidine carbonate in 1:2 molar ratios. The structure of all these compounds were established on the basis of elemental analysis, IR and PMR spectral data. All the synthesized compounds have been assayed for their antibiological activity against both gram-positive and gram-negative human pathogens and found that they possess insecticidal, and bacteriocidal.  Some 1,3,5-thiadiazine compounds show remarkable biological activity.

Keywords

1,3-Bis-(n- substitutedthioamido) guanidine, 1,3,5-thiadiazines, antimicrobial activity

Article Metrics

Article View: 0

Share This Article

© The Author(s) 2007. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.