The study focused on statistical optimization of Nilavembukudineer using RSM and its antibacterial activity. The combined interactive effect of different variables on Nilavembukudineer production was studied by Response Surface Methodology (RSM). The efficiency of the antibacterial compound was tested against clinical isolate of Salmonella typhi. The variables are Andrographis paniculata, Piper nigrum, Plectranthusvetti veroides, Zingiber officinale, Santalum album, Cyperus rotandus, Hedyotis corymboa, Trichosanthes cucumerina and Vetiveria zizanoides.This study suggest that RSM mediated optimization can be a good method for the enhancement of antimicrobial activity of Nilavembukudineer. In future, this method can be very good alternative method of siddha traditional based optimization.
Nilavembukudineer, Salmonella typhi, antibacterial activity, RSM
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