ISSN: 0973-7510

E-ISSN: 2581-690X

Rekha Bachhiwal, Anita Singhal , Suman Rishi, Leela Vyas, Rameshwari Bithu and Saroj Hooja
Department of Microbiology, SMS Medical College, Jaipur – 302 018, India.
J Pure Appl Microbiol. 2012;6(3):1489-1492
© The Author(s). 2012
Received: 25/12/2011 | Accepted: 27/02/2012 | Published: 30/09/2012
Abstract

The present study was carried out to determine the seropositivity of IgM antibodies to toxoplasma and to assess its role in pregnancy wastage in women with bad obstetric history. This study was conducted at a tertiary care hospital in West of Rajasthan. The study population consisted of 250 women aged 18-35 years with history of two or more pregnancy wastages in the form of abortions, stillbirths, preterm deliveries and /or congenital anomalies. Fifty healthy women with no bad obstetric history were taken as controls. Serum samples obtained from these cases were evaluated for IgM antibodies to toxoplasma by ELISA method. The overall seropositivity of IgM antibodies to toxoplasma was found to be 55/250(22%) among the study group. Among the control group seroprositivity was 1/50(2%). The difference was statistically significant (P=0.00092). Maximum number of patients under study had history of abortion 187/250 (74.8%) followed by congenital anomalies 34/250 (13.3%), still births 15/250(6%) and preterm deliveries 14/250 (5.6%). Seropositivity  for IgM antibodies to toxoplasma was maximum among abortion cases 47/187(25.13%) followed by congenital anomalies 5/34 (14.7%), still births 2/15 (13.33%) and preterm deliveries 1/14 (7.14%). The presence of Toxoplasma IgM antibodies to toxoplasma in the serum of cases with abortions (47/187) showed a significant association (p=0.039). History of contact with animals particularly cats was significant in seropositive cases. (p=0.003) The current study reveals a significant correlation between IgM antibodies to toxoplasma and pregnancy wastage.

Keywords

TORCH, Bad Obstetric History, Abortions, Toxoplasma gondii

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