Desferrioxamine B is a hydroxamate-type siderophore originally isolated from S. pilosus, and has been used to treat thalassemia major patients by chelating overloaded iron. Multiple reports of production of desferrioxamines in streptomycetes were reported, however the distribution of desferrioxamines were still not clear. To examine the distribution of desferrioxamines in streptomycetes, we performed HPLC screening using 41 streptomyces strains. The production of desferrioxamines was detected in high percentage (78%, 32/41) of streptomycetes, which indicated that desferrioxamines were widely distributed in streptomycetes.
Siderophore, Streptomyces, Desferrioxamines, HPLC, ESI-MS
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