ISSN: 0973-7510

E-ISSN: 2581-690X

Fumiya Kobayakawa1 and Shinya Kodani1,2
1Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan.
2Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan.
J Pure Appl Microbiol. 2012;6(4):1553-1558
© The Author(s). 2012
Received: 10/12/2011 | Accepted: 12/01/2012 | Published: 31/12/2012
Abstract

Desferrioxamine B is a hydroxamate-type siderophore originally isolated from S. pilosus, and has been used to treat thalassemia major patients by chelating overloaded iron.  Multiple reports of production of desferrioxamines in streptomycetes were reported, however the distribution of desferrioxamines were still not clear.  To examine the distribution of desferrioxamines in streptomycetes, we performed HPLC screening using 41 streptomyces strains.  The production of desferrioxamines was detected in high percentage (78%, 32/41) of streptomycetes, which indicated that desferrioxamines were widely distributed in streptomycetes.

Keywords

Siderophore, Streptomyces, Desferrioxamines, HPLC, ESI-MS

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