New coumarin derivatives namely (5-oxo-chromeno[3,2-c] dihydropyran derivatives 2a,b, 3a,b ),(3 -acetyl-4-aryl -2-methyl-5-oxo-chromeno[3,2-c]2,3,4-trihydropyran 4a,b ), ( 2-amino-5-oxo-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile 5a,b and 2-amino-5-oxo-3,4,4a,10b-tetrahydro-2H,5H-pyrano[3,2-c]chromene-3-carboxylic acid amide 6a,b) were synthesized starting from 3-arylidene chromen-2,4-dione derivatives. The structures of the obtained compounds were confirmed by analytical elemental analysis, IR, 1H-NMR and mass spectra. The new compounds were screened for their antibacterial activity .Compound 3a was the most active compound against gram positive and gram negative bacteria.
Active methylene, Coumarin derivatives, Biological activity
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