Reaction and Antibacterial Efficacy of Active Methylene Compounds with Coumarin Derivatives

ISSN: 0973-7510

E-ISSN: 2581-690X

A.Y. Soliman¹, F.K. Mohamed¹, Ramadan M. Abdel-Motaleb¹, Rasha M. Abdel-Rahman⁶ , A.M. Abdel-Mohsen^2,4, Moustafa M.G. Fouda^3,4, Salem S. Al-Deyab³ and Asmaa S. Mohamed⁵

¹Department of Chemistry, Faculty of Science, Fayoum University, Fayoum, Egypt.

²Central European Institute of Technology (CEITEC), Brno University of Technology, Czech Republic.

³Petrochemical Research Chair, Department of Chemistry , College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.

⁴Textile Research Division, National Research Center, Dokki, Giza, P.O. 12622, Giza 12522, Egypt.

⁵Department of Medical Chemistry, Theodor Bilharz Research Institute, Egypt.

⁶Institute of Organic Chemistry and Technology, University of Pardubice, Czech Republic.

J Pure Appl Microbiol. 2013;7(Spl. Edn.: November):435-439

Received: 01/10/2013 | Accepted: 05/11/2013 | Published: 30/11/2013

Abstract

New coumarin derivatives namely (5-oxo-chromeno[3,2-c] dihydropyran derivatives 2a,b, 3a,b ),(3 -acetyl-4-aryl -2-methyl-5-oxo-chromeno[3,2-c]2,3,4-trihydropyran 4a,b ), ( 2-amino-5-oxo-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile 5a,b and 2-amino-5-oxo-3,4,4a,10b-tetrahydro-2H,5H-pyrano[3,2-c]chromene-3-carboxylic acid amide 6a,b) were synthesized starting from 3-arylidene chromen-2,4-dione derivatives. The structures of the obtained compounds were confirmed by analytical elemental analysis, IR, 1H-NMR and mass spectra. The new compounds were screened for their antibacterial activity .Compound 3a was the most active compound against gram positive and gram negative bacteria.

Keywords

Active methylene, Coumarin derivatives, Biological activity

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