Coenzyme Q10 is industrially produced by fermentation and extraction from Rhodobacter sphaeroides. However, phage pollution is a fatal phenomenon in the fermentation industry. The infection of R. sphaeroides by phase was reported for the first time in this study. Based on the obtained genetic sequence from the phage, a quantitative polymerase chain reaction (qPCR) phage detection profile was developed for early detection during the pilot culture to prevent phage pollution in the production lines.
Rhodobacter sphaeroides, phage pollution, phage detection, qPCR
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