ISSN: 0973-7510
E-ISSN: 2581-690X
The resistance to antimicrobial agents among staphylococci is a major concern worldwide. This study was undertaken to find out the presence of inducible clindamycin (iMLSB) resistance among hospital and community associated staphylococci in our geographical area. A total of 560 staphylococci isolates from various clinical samples were studied. Inducible clindamycin resistance was detected by “D-test” using erythromycin and clindamycin discs as per CLSI guidelines. Three hundred seventy four (66.79%) isolates were hospital acquired and 186(33.21%) community associated. The overall prevalence of iMLSB was 122(21.78%). Community associated staphylococci revealed significantly lower prevalence of iMLSB (14.51% versus 25.40%) and higher rate of constitutive cMLSB (9.67% versus 2.67%) resistance compared to hospital acquired. iMLSB resistance was predominant among MRSA 70.11% and least among MSCONS 4.2%. Majority of iMLSB isolates were sensitive to gatifloxacin 87.70%, amikacin 80.32% and resistant to ampicillin 99.18%, ciprofloxacin 68.03%. The occurrence of iMLSB resistance in hospital as well as community set up raises concern of clindamycin treatment failure. It is essential to include “D-test” to detect inducible clindamycin resistance in routine antimicrobial susceptibility testing for the optimum treatment of patients.
Clindamycin, Community, D-test, Hospital, Staphylococci
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