ISSN: 0973-7510

E-ISSN: 2581-690X

Anasuya K. Patil, B.M. Dinesh and Shivanand Hiremath1
K.L.E.Scociety’s College of Pharmacy, II Block Rajajinagar, Banagalore – 560 010, India.
1H.K.E.S.College of Pharmacy, Gulbarga – 585105 India.
J Pure Appl Microbiol. 2007;1(2):317-322
© The Author(s). 2007
Received: 15/09/2007 | Accepted: 08/10/2007 | Published: 30/10/2007
Abstract

The main objective of the present study is to prepare solid dispersions and controlled drug delivery systems of felodipine, a poorly water soluble drug. With a view to improve the dissolution rate and promote uniform absorption and enhance bioavailability. In the current work, an attempt was made to prepare solid dispersion (common solvent method) by using PEG-6000 in the ratio of 1:1,1:2,1:3,1:4 and 1:9 drug polymer ratio. The complexes were studied for the in-vitro drug release. The dissolution profile shows 1:9 drug-polymer ratio complex gave higher dissolution rate. Further, the complex (1:9) was used to prepare agar spherules in the ratio of 1:5 and 1:10 drug/complex: agar ratio. These prepared spherules were studied for in-vitro drug release pattern. The in-vitro drug release data were plotted according to zero order, first order and Higuchi’s diffusion model. The former did not yield linear plot. The data were subjected to linear regression analysis and correlation co-efficient values for Higuchi’s plots are nearly approaching unity and hence it can be said that, the drug release in agar spherules occurs by diffusion through the hydrophilic matrix.

Keywords

Agar spherules, Felodipine, Drug delivery system

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© The Author(s) 2007. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.