ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Sachidanandam Magesh1,2 , Krishnasamy Kaveri1, Palani Gunasekaran1 and Karuppanan Sathiyamurthy2 
1Department of Virology, King Institute of Preventive Medicine and Research, Chennai – 600 032, Tamilnadu, India.
2Department of Biomedical Science, School of Basic Medical Sciences, Bharathidasan University, Trichy – 620 024, Tamilnadu, India.
J Pure Appl Microbiol, 2019, 13 (3): 1555-1560 | Article Number: 5820 | © The Author(s). 2019
Received: 06/08/2019 | Accepted: 08/09/2019 | Published: 24/09/2019

C-reactive protein (CRP) in the form of high sensitivity CRP (hs-CRP) is one of the better extensively used risk marker for the coronary artery disease (CAD) in clinical practice. Increased value of hs-CRP has been related with increased threat for the development of blood pressure, stroke, peripheral arterial disease, temporary ischemic attack and sudden coronary deceased condition. If hs-CRP involves a fundamental role in atherothrombosis, then hs-CRP is the better biomarker proposed to be necessary for improving to detect the risk of coronary events of arterial disease. In this study, the HCV seropositive patients (by Anti HCV-IgG Indirect Elisa) more than 2 years old, hepatic and leukaemia were investigated for extra hepatic manifestation. The Lab request forms with questionnaire were together including CRP, HS-CRP, serum cholesterol and liver function tests were scrutinized. Total of 170 cases (around the Chennai) was taken for the study. In which, 45.3% of cases were observed as hepatitis patients with ALL cases. The other 8% of cases were having liver cirrhosis and rest of the cases was not having cirrhosis. Finally, the study explores the relationship between the HCV seropositive of leukaemia cases, HCV RNA and CRP, hs CRP with cirrhosis. These evaluations point out that HCV infection may amend the chronic inflammatory condition in leukaemia patients. Additionally, the results recommended that screening for hs-CRP should be considered previous to evaluation of cardiovascular risk in HCV patients, because the results may affect the risk scoring of coronary artery disease.


Hepatitis C Virus, Coronary artery disease (CAD), hs-CRP, Leukaemia.

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© The Author(s) 2019. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.