Aqueous extract of Clinacanthus nutans leaves were used as a biological source for the reduction of silver nitrate into silver nanoparticles. Result obtained from UV-Visible analysis exhibit the absorption peak at 460 nm confirms the production of silver nanoparticles. FTIR analysis showed the presence of alkyne, alcohol and primary amine that are responsible for reduction and stability of nanoparticles. The size of silver nanoparticles based on TEM analysis showed size from 6.26nm until 26.77nm and are in spherical shape. These nanoparticles showed good antibacterial activity and good synergistic effect in combination with different antibiotics such as amikacin, rifampicin, ofloxacin, moxifloxacin, piperacillin and levofloxacin against Escherichia coli, Klebsiella pneumonia and Staphylococcus epidermidis were studied.
Silver nanoparticles, Clinacanthus nutans, UV-Visible, FTIR analysis TEM analysis, Antibacterial effect.
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