ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Shahnaz Majeed* and Muhammad Syahmi Bin Abdul Samad
Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur, Royal College of Medicine Perak Malaysia – 30450, Malaysia.
J Pure Appl Microbiol, 2019, 13 (2): 1267-1272 | Article Number: 5660
Received: 10/05/2019 | Accepted: 16/06/2019 | Published: 27/06/2019
Abstract

Aqueous extract of Clinacanthus nutans leaves were used as a biological source for the reduction of silver nitrate into silver nanoparticles. Result obtained from UV-Visible analysis exhibit the absorption peak at 460 nm confirms the production of silver nanoparticles. FTIR analysis showed the presence of alkyne, alcohol and primary amine that are responsible for reduction and stability of nanoparticles. The size of silver nanoparticles based on TEM analysis showed size from 6.26nm until 26.77nm and are in spherical shape. These nanoparticles showed good antibacterial activity and good synergistic effect in combination with different antibiotics such as amikacin, rifampicin, ofloxacin, moxifloxacin, piperacillin and levofloxacin against Escherichia coli, Klebsiella pneumonia and Staphylococcus epidermidis were studied.

Keywords

Silver nanoparticles, Clinacanthus nutans, UV-Visible, FTIR analysis TEM analysis, Antibacterial effect.

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© The Author(s) 2019. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.