ISSN: 0973-7510

E-ISSN: 2581-690X

Sherif H. Abd-Alrahman1 , Mounir M. Salem-Bekhit2, Manal E.A. Elhalwagy3, Wael M. Abdel-Mageed4,5 and Awwad A. Radwan2,6
1Biochemistry Department, College of Science, King Saud University, PO Box, 2455, Riyadh, 11451, Saudi Arabia.
2Department of Pharmaceutics, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh, Saudi Arabia.
3Biochemistry Department, Faculty of Science for Girls, King Abdulaziz University, P.O Box 51459, Jeddah,-21453, KSA.
4Pharmacognosy Department, College of Pharmacy, King Saud University, Riyadh 11451, P. O. Box 2457, Saudi Arabia.
5Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
6Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
J Pure Appl Microbiol. 2013;7(Spl. Edn.: November):813-818
© The Author(s). 2013
Received: 12/08/2013 | Accepted: 24/10/2013 | Published: 30/11/2013

The Ziziphus species (Rhamnaceae family) are considered to be multipurpose plants and have been used as foods, folklore medicines, the environmental protection plants. This study was conducted to isolated and evaluate the antimicrobial activity of ethanol extract of Ziziphus jujuba seeds against sixe bacterial strains by determining minimum inhibitory concentration (MIC) and analyzed  their  content  by  using  chromatographic techniques  to identify  the  principal  bioactive  phytochemicals. GC/MS analysis of ethanol extract of Ziziphus jujuba seed revealed the existence of 20component, main components were 13-Heptadecyn-1-ol (12.95%), 7-Ethyl-4-decen-6-one (9.73%), Lineoleoyl chloride (8.54%), Linoleic acid (6.37%), 2,5-Octadecadiynoic acid, methyl ester (5.57%) and Palatinol A (4.81%). The results indicated that the ethanolic extract of Ziziphus jujuba seed contains a many bioactive components that could have advantage offer a platform of using Ziziphus jujuba seed as herbal alternative for the current synthetic antimicrobial agents.


Phytochemical Screening, Antibacterial activity, Ziziphus jujuba, Medicinal plants

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© The Author(s) 2013. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.