Application of electrophotocatalytic (EPC) methods for drinking water disinfection was broadly used in the recent years. These methods led to producing of strong oxidant agents such as hydroxyl (OH^–) radical. The goal of this applied-analytical research was to investigate of Streptococcus faecalis (S. faecalis), as a microbial indicator, removal from urban drinking water by batch EPC reactor with using zinc oxide (ZnO) nanoparticles immobilized on zinc (Zn) sheet-copper electrode, and lamp emitting dynode (LED) ultraviolet-A (UV-A) lamp. The contaminated water sample was prepared by adding 5×10¹-5×10² cells of S. faecalis bacteria per ml of drinking water. The studied variables were pH (6-8), the number of bacteria (5×10¹-5×10² cells / ml), the lamp intensity (120-360 mW cm^-2), radiation time (5-30 min), the distance between lamp and electrode (1.5 cm), layering of zinc oxide nanoparticles (1-3), and current density (3-9 mW cm^-2). The results showed the correlation between removal of cells and UV-A lamp intensity, current density, and radiation time. Optimal removal (0) was obtained at pH 8, radiation time: 5 minutes, 2- layer of ZnO nanoparticles, and current density of 3 mW cm^-2. The findings indicated that removal efficiency was increased with increasing current density, radiation time, and lamp intensity.