Nuclease Composition with Anti-Rabies Activity

ISSN: 0973-7510

E-ISSN: 2581-690X

Nailya Khismatullina¹, Arkadiy Ivanov¹, Ekaterina Martynova², Alexander Mironov¹, Elmira Zainutdinova², Svetlana Khaiboullina², Albert Rizvanov² and Maria Filimonova²

¹Federal Center for Toxicological, Radiation and Biological Safety, 420075, 2-Nauchniyi gorodok, Kazan, Tatarstan, Russia.

²Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008,
Kremliovskaya st. 18, Kazan, Tatarstan, Russia.

J Pure Appl Microbiol. 2014;8(Spl. Edn. 2):499-504

Received: 02/08/2014 | Accepted: 19/09/2014 | Published: 30/11/2014

Abstract

A composition demonstrating anti-rabies activity was developed on the basis of isoform Sm1 of Serratia marcescens endonuclease. Besides the enzyme the composition contained Haemodes-N, magnesium sulfate and sodium chloride. Injection of this composition at a mouse’s infection cite, two hours after the mouse has been infected with rabies, showed an increase of the infected animals’ survival by more than 30% in comparison with the animals of control group.

Keywords

Nuclease, Serratia marcescens, Sma nuc, Rabies, Postexposure protection

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