ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Chandra Mohan Singh Bisht1, S.M. Shakeel Iqubal2   , Aejaz A. Khan2,Tasneem Mohammed2 , Areej Dawoud2, Mohammed Gamal3,4 , S.K. Singh5 and Basim H. Asghar6
1Department of Applied Science, IIMT College of Engineering, Greater Noida – 201 301, India.
2Department of General Science (Chemistry), Ibn Sina National College, Jeddah, Saudi Arabia.
3Pharmaceutical Chemistry Department, Faculty of Pharmacy, Jouf University, Skaka 2014, Kingdom of Saudi Arabia.
4Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, AlshaheedShehata Ahmed Hegazy St., 62574 Beni-Suef, Egypt.
5Department of Chemistry, GGV (Central University), Bilaspur, Chhattisgarh – 495 009, India.
6Department of Chemistry, Faculty of Science, Umm Al-Qura, University, Makkah, Saudi Arabia.
J Pure Appl Microbiol, 2019, 13 (3): 1611-1617 | Article Number: 5750 | © The Author(s). 2019
Received: 29/07/2019 | Accepted: 06/09/2019 | Published: 25/09/2019

Natural products are an excellent source of therapeutic products which has led to the discovery of many important drugs that play an important role in the treatment of various human diseases. In this current study two compounds has been isolated from Senecio royleanus DC. (Asteraceae) were undertaken for antibacterial and antifungal activity against five bacterial and fungal pathogens. The compounds isolated from Senecio royleanus, viz; 1,10b-epoxy 6-oxo-furanoeremophilan and 1b, 10-epoxy-furanoeremophilan displayed a very important role against all bacterial and fungal strains. 1,10 b-epoxy 6-oxo-furanoeremophilan showed maximum antibacterial activity against Agrobacterium tumefaciens (13 mm). While it showed maximum fungal activity against Fusarium oxysporum (15 mm). 1b,10-Epoxy-furanoeremophilan was found inactive in antibacterial activity against Escherichia coli, and showed maximum zone of inhibition against bacterial strain of Bacillus subtilis (12 mm) . It showed 12 mm zone against Rhizoctonia solani during antifungal activity. The fractions which showed significant antimicrobial activity i.e. (zoi ³ 10 mm), were further tested to find out minimuminhibitory concentration and minimum bactericidal concentration at different concentrations.


Asteraceae/aenecio, royleanus, Antifungal activity, Antibacterial activity.

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© The Author(s) 2019. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.