ISSN: 0973-7510

E-ISSN: 2581-690X

Jiao Xiong1 and Yang Lifeng2
1Institute of Applied Mechanics and Biomedical Engineering, Taiyuan University of Technology, Taiyuan – 030 024, China.
2College of Computer Science and Technology, College of Software, Taiyuan University of Technology, Taiyuan – 030 024, China.
J Pure Appl Microbiol. 2013;7(Spl. Edn.: April):405-410
© The Author(s). 2013
Received: 03/03/2013 | Accepted: 14/04/2013 | Published: 30/04/2013

Talin is an important linking between integrin and the actin cytoskeleton. In the process of signal transduction, talin play a critical role in the bidirectional signal transfer. In this paper, we analyze the motion modes of talin rod domain with the Gaussian network model. The results show that the two free terminals move in a negative correlated way, and this large-scale conformational change trend rest with the topological characteristics of the structure. For the peaks of the fast modes, it corresponds to some residues, and these residues are important to the stability of the structure. They may also act as key residues when they talin interacted with integrin or other signaling molecules. As an inherent feature of the structure, these motion modes are determined by the topology character of the structure. These results can provide a better understanding of the motion trend of talin in the process of signal transfer.


Talin, Rod Domain, Motion Mode, Gaussian Network Model

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© The Author(s) 2013. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.