Bronchiectasis is one of the complicated diseases of lower Respiratory Tract. Present study was done to analyze the pattern and antibiotic resistance of bacterial isolates in BE cases.  BAL samples were collected from 150 patients, and identified by standard methods. Antibiotic susceptibility of isolates was done by Kirby-Bauer method, from 56 (37.3%) out of 150 BE cases PPMs were isolated. The most frequent isolates were S.aureus (21 cases; 37.5%) and Klebsiella spp. (16 cases; 28.5%), Three (37.5%) out of 8 Acinetobacter isolates were resistant to imipenem. All of the citrobacter isolates were sensitive to imipenem, Cefepiem, gentamicin, ceftriaxon and ciprofloxacin, and Klebsiella isolates were sensitive to all mentioned antibiotics except than ceftriaxone. In gram positive isolates 8(38%) and 3(14%) out of 21 S.aureus isolates were resistant against methicillin and vancomycin respectively. The most high sensitivity in S.aureus isolates was seen against vancomycin(86%) and then ceftriaxon (71.46%) and tetracycline(71.46%). Results of present study clearly indicates that majority of isolates from BE cases have resistance against commonly used and in some cases choice antibiotics. These findings alarming the health and hospital officials, and emphasizing that screening and surveillance programs should be implemented in necessary conditions.