The objective of our research was to explore metabolic characteristics of the deep-sea fungi in extreme environment. The study revealed a rather low population density of cultivable fungi in deep-sea sediments. Sixteen compounds, including nine cyclic dipeptides (1-3, 8, 9, 12, and 14-16), were obtained from the fermentation broth of the Cladosporium sp. FA1-2 derived from the Atlantic Ocean. The deep-sea fungal metabolic characteristics in low temperature and oligotrophic medium were reported here for the first time. The characteristics of metabolites were connected with the adaptive mechanism of deep-sea fungi and could be used as a reference to study the secondary metabolites of fungi residing in extreme environments.
extreme environments; metabolic characterization; deep-sea fungus; Cladosporium sp..
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