Every year about 300-500 million individuals catch malaria throughout the world and 2-3 million of them who are mostly children and pregnant women die. Most malaria cases in Iran are reporting from Sistan and Baluchistan, Kerman and Hormozgan provinces, but there is still the risk of roll back malaria and it’s again incidence in eradicated areas, so it is still possible to incidence of epidemics in endemic area. Eradication of disease and prevention are one of the main policies of Department of Health of I.R.Iran. This research is conducted to determine the epidemiological aspects of this disease in Bushehr province, southern Iran. This Retrospective study is conducted based on statistical data collected from different Health Centers of Bushehr province from 2001-2008. A questionnaire including different variables such as age, sex, year, nationality, type of the parasite and township were designed. Data were analyzed using SPSS software program. The total number of 1470 cases of disease is registered within eight years. Most of the cases belonged to Bushehr and Kangan cities, due to Plasmodium vivax parasite. Local transmission was recorded in 11% of the cases and 98% of local transmission have been occurred in Kangan city. Elimination of Malaria is based on effective and successful operation specially developing intervention with controlling the vectors and medical care and treatment of new identified cases of disease. Considering that patients have foreign nationality who enters the province as workers, so having accurate and cohort program to identify the fire places, quick identification of cases, public training, review and accurate classification of disease cases with special treated measures of tactical program in national level can help the elimination of the Malaria.