Leptospirosis is a bacterial disease that affects humans and animals. It is caused by a bacterium of genus Leptospira. It is estimated that 10 million are infected with leptospira each year and it is difficult to estimate exactly how many of them die from this condition, in large measure by which the deaths occur in countries where the deaths are not subject to routine reporting¹. Is considered to be an emerging disease in many countries². The infection can cause fever, renal failure and pulmonary hemorrhage and is potentially fatal in 5% to 15% of cases^{3,4,5, 11}.

The leptospirosis is known by different names: Weil disease, disease of those tending the pigs ran off, fever of the rice paddies, fever of the reed beds, and so on². It is a zoonotic disease , the animals most affected are the dogs, cattle, and pigs³. Leptospirosis in animals is often subclinical, and with high concentrations of bacteria in urine, without clinical evidence of disease³.

The etiologic agent  includes 2 species: L. interrogans, pathogenic for animals and humans and L. biflexa, which is of free life. L. interrogans is divided into over 210 serovars and 23 serogroups. This classification has epidemiological importance since the clinical picture and in general the virulence is not related to the serovar. You can survive for any length of time in the water or moist environment, temperate, with pH neutral or slightly alkaline⁴.

The at-risk population corresponds to endemic areas of developing tropical countries; in developed countries it is occupational disease of those working with animals (farmers, veterinarians, farmers, dairy, butchers, workers of refrigerators or sanitation and farmers), its products or polluted, especially with rodents; man can become infected in recreational activities in contact with contaminated stagnant water (bath, water sports, fishing) or contact with your pet, inhaled aerosols can be transported  microorganisms directto the lungs. Transplacental transmission is possible³.

In Mexico the registration of leptospirosis starts until the year 2000 on the system of weekly reporting of new cases of disease subject to surveillance epidemiological. from 2001 to 2012 has generated a report of 2,001 cases  etween 2003 and 2012, 50% of the cases were men and 50% women, the highest rate of reported cases are Chiapas, Veracruz, Sonora, Tabasco and Sinaloa⁵.

The clinical manifestations acute are variables, incubation period of 2 to 20 days, stress symptoms influenza, conjunctival injection, fever^6,7, myalgias in legs and thighs that limit the march, retroocular pain, photophobia, exanthema morbiliforme, petequias in palate, nausea, vomiting, abdominal pain and diarrhea, the symptoms are parallel to the phase leptospirémica, they autolimit themselves from 7 until 10 days later with the beginning of the immune phase (the second week), 10 % with hemorrhage in skin and mucous membranes, partner to plaquetopenia, jaundice, and respiratory renal flaw for diffuse alveolar hemorrhage, and the shock state, the severe and potentially mortal form of lepstospirosis ictérica is the Weil illness, the fever reappears associated with meningitis hemólisis, miocarditis, corioretinitis, sharp and respiratory renal flaw^8-11.

Clinical picture. The clinical manifestations are highly variable characterized by high fever, headache, chills, muscle pain, and vomiting, you can include jaundice, conjunctivitis, abdominal pain, diarrhea, or rash.  The diagnosis of leptospirosis should be considered in any patient that this sudden fever, chills, headache, jaundice and conjunctival injection, myalgia most notable in the areas lumbar and calves which constitute one of the symptoms most distinctive of the disease. Laboratory findings in samples of hospitalized patients show high rates of ESR, thrombocytopenia, leukocytosis, hyperbilirubinemia, and elevated levels of serum creatinine, creatinine kinase and serum amylase¹.

Case history
An case report was conducted in 34-year-old male worker on a farm in the care of animals, with a picture of 8 days of evolution with fever, chills, headache, cough, dyspnea, nausea, vomiting, abdominal pain, hyposthenia from, hypodynamy, epistaxis, expectoration, gingival bleeding, petechiae, congestion conjunctival bilateral, lumbar pain; to the physical exploration, febrile, hypotensive, tachycardia, tachypnea, icteric, dehydrated, confused, disoriented, subconjunctival hemorrhage bilateral, rales bilateral basal adenomegaly, generalized maculopapular rash predominating in the thorax and abdomen, hepatomegaly, abdominal pain, not peritoneal irritation.

Laboratory studies
Hyperbilirubinemia to predominance of the direct one, hiperamilasemia, transaminasemia, phostatase alkaline raised, hipokalemia, time of long prothrombin, normochromic anemia, thrombocytopenia, leukocytosis, neutrophilia, bandemia, high CPK, azotemia, proteinuria, hematuria, blood culture and   urine culture of revenue negatives, arterial gas with hypoxemia and desaturation, kirby’s index under, short circuits  intrapulmonary and the difference alveolar-arterial of oxygen raised. With positive antibodies against leptospira, 1:320, (skill of immunofluorescence), it isolated itself Leptospira icterohaemorrhagiae. electrocardiogram: sinus tachycardia, and ventricular extrasystoles Chest x-ray: pulmonary infiltrates bilateral diffuse.

Evolution of the patient
Evolution torpid, hemodynamic instability, acute respiratory failure, anuria, and progressive deterioration multisystemic, required hidroelectrolitic treatment, vasoactive amines, orotracheal intubation and ventilatory support mechanical, maneuvers of alveolar recruitment for protection pulmonary, and antimicrobials triple coverage, without reply in the first 5 days of treatment to support multiple organ failure, blood and urine cultures of income, is interrogated to family, has been reported as a worker on a farm in the care of animals (pigs, dogs, sheep, chickens, horses), lived in a cellar where they stored grains and canned beverages, which were ingested without cleaning them. On the basis of the results starts doxycycline 200 mg every 12 hours, with clinical response clear and progressive, with retrievability of cardiac dysfunction, respiratory and renal, became independent from the infusion of amines vasopresoras and ventilatory support, in a period of 72 hours, the treatment was completed by 10 days, with total remission of the table of organ dysfunction.