Gram positive coccal bacteria were isolated from 16 of the 65 samples representing 24.62% of the organisms responsible for neonatal septicaemia. Of this number (16), ten (62.5%) were Staphylococcus species, with a prevalence of 15.38%. S. aureus was isolated from five (5), representing 31.25%, with a prevalence of 7.69%. CONS accounted for the remaining five (5) (7.69%) of the isolates. b-haemolytic Streptococcus sp had a prevalence of 9.23% and accounted for 37.5% of the isolates, being the predominant organism responsible for neonatal septicaemia in the study area. 60% of the Staphylococcus aureus isolates were sensitive to chloramphenicol, augmentin and amoxicillin, 40% to cotrimazole, erythromycin and tetracycline and 20% were sensitive to gentamicin and cloxacillin. Strains AB-010 and AB- 061 exhibited multiple resistance to most of the antibiotics. The mean zone of inhibition ranges from 26mm for gentamicin and cloxacillin to 34.3 mm for augmentin. All Streptococcus strains were sensitive to gentamicin while 83.33% were sensitive to chloramplenicol. The least sensitivity was to tetracycline which was 50%. The mean zone of inhibition ranges from 29.4mm for gentamicin to 36.5 mm recorded for cotrimazole The CONS isolates were 100% sensitive to Chloramphenicol, augmentim and amoxicillin. 80% were sensitive to gentamicin, cotrimazole and cloxacillin while 40% were sensitive to erythromycin and tetracycline. The mean zone of inhibition ranges from 30mm for tetracycline to 35.5 mm recorded for cloxacillin