Oxidative processes may be increased in patients with chronic renal failure (CRF), and this is a possible factor contributing to the development of anemia and atherosclerosis, which are characteristic complications of CRF. The objective of the present study was to determine the antioxidant activity of Calocybe indica (Edible mushroom) against mercury chloride induced haemolysis in chronic renal failure patients. The analysis includes the estimation of TBARS, G-S-H, superoxide dismutase, catalase, vitamin C and vitamin E. Variation in glucose, lipid profile and haematological parameters such as erythrocyte count and haemoglobin were also assessed before and after haemolysis when compared with the control group. The results of the present study revealed elevated levels of TBARS and G-S-H in CRF patients and mercury chloride treated subjects.The levels of enzymatic, non-enzymatic antioxidants were found to be decreased in chronic renal failure patients and mercury chloride treated subjects. Further more, the level of haematological and lipid parameters were altered in CRF and mercury chloride treated patients. To conclude the addition of Calocybe indica extract was found to reverse the lipid peroxidation effect on mercury chloride induced haemolysis in CRF patients. The phytochemical analysis of Calocybe indica indicates the presence of phenols, b-carotene and lycopene which contributes to the antioxidant activity of Calocybe indica. Therefore, it has been suggested that Calocybe indica may serve as an antioxidant supplement for CRF patients.
Antioxidants, Calocybe indica, Haemolysis, Chronic renal failure, Bioactive compounds
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