In vitro Antimicrobial, Antioxidant and Cytotoxic Activities of New Pregnane Glycosides and Pregnanes Isolated from the Carallum adescendens var. gracilis and Caralluma pauciflora

ISSN: 0973-7510

E-ISSN: 2581-690X

In vitro Antimicrobial, Antioxidant and Cytotoxic Activities of New Pregnane Glycosides and Pregnanes Isolated from the Carallum adescendens var. gracilis and Caralluma pauciflora

Kommidi Devendar Reddy¹ , Kandappa Himakar Reddy², Ghanakota Venkateshwer Rao³, Moodley Brenda¹, Govender Patrick² and Neil Anthony Koorbanally¹

¹School of Chemistry and Physics, University of KwaZulu-Natal, Wesville, Durban, South Africa-4000.

²Department of Biochemistry, University of KwaZulu-Natal, Wesville, Durban, South Africa-4000.

³Department of Chemistry, Kakatiya University, Warangal, Andhrapradesh, India-506009.

J Pure Appl Microbiol. 2013;7(4):2707-2712

Received: 19/01/2013 | Accepted: 03/03/2013 | Published: 30/12/2013

Abstract

Since ages plants and their products are an inseparable part of mankind in the treatment of the various diseases as they are a good source of different types of chemical constituents and Secondary metabolites. Medicinal uses of Caralluma species have been reported in the treatment of cancer, inflammatory diseases, diabetes, tuberculosis skin rashes, leprosy, and diseases of blood, snake and scorpion bites. The present study deals with the in-vitro anti microbial, anti fungal and antioxidant Activities of one pregnane (CPG-I) glycoside and two pregnanes (CP-I&CP-II) from Caralluma pauciflora (Asclepiadaceae). The compounds were tested against bacteria and fungi to determine the Antimicrobial and anti fungal activity by the micro broth dilution method. In-vitro antioxidant activity of these compounds was evaluated using DPPH free radical scavenging, H₂O₂ and reducing power methods. The steroidal glycoside (CPG-I) and pregananes (CP-I&CP-II) showed good antimicrobial, anti fungal and anti-oxidative activity. The results indicate that plant derived compounds could be an alternative to the current available pharmaceutical drugs in the market.

Keywords

Broth dilution, free radical scavenging activity, cytotoxic, Caralluma adscendens var gracillis, Caralluma pauciflora

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