ISSN: 0973-7510

E-ISSN: 2581-690X

Mohamed A. Dkhil1,2 , Denis Delic3 and Saleh Al-Quraishy1
1Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
2Department of Zoology and Entomology, Faculty of Science,Helwan University, Cairo, Egypt.
3Department of Biology, Heinrich-Heine-University, Duesseldorf, Germany.
J Pure Appl Microbiol. 2014;8(5):3891-3896
© The Author(s). 2014
Received: 20/08/2014 | Accepted: 12/09/2014 | Published: 31/10/2014

The study aimed to investigate antiviral properties of orange peel methanolic extract against herpes simplex virus type 1 and 2 (HSV-1 and 2) in vitro. HSV-infected Vero cells and cell-free virus suspensions were treated with orange peel extracts, and virus yield and infectivity were quantified by direct plaque assay. The results of the present study showed that orange peel methanolic extract at 100µg/ml provided 68.5% inhibition against HSV-1. In addition, orange methanolic extract at 100 µg/ml provided 72.8% inhibition against HSV-2. The extract showed 100% inhibition against HSV-1 and 2 at 200, 250 and 300 µg/ml. These properties suggest that this orange peel could provide advantage as a topical prophylactic/therapeutic agent for herpes infections.


Antiviral, Orange peel, Herpes simplex virus

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© The Author(s) 2014. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.