Birds truffles; Picoa spp. have been subject to few studies. Birds truffles are considered among desert truffles and a valuable food. Further, they were used as medicine in Arabian Gulf countries including Saudi Arabia and several other countries of the world. Recently, many researchers have demonstrated that desert truffles including bird’s truffles are source of important nutritional elements. In addition, they have some biological activities such as antibacterial, antioxidant activities, kind of medicinal properties and used in folk medicine. Meanwhile, birds truffles were not investigated for its cultivation, ecology, taxonomy, physiology, edibility, medicinal properties as well as antimicrobial activities. Rare studies on birds truffles could be found in surveyed literatures concerning geographic distribution and molecular studies. These molecular research were achieved to elucidate the ambiguity of the classification of birds truffles; this with the help of the advanced recent techniques in molecular biology. Hence, in this present article, we compile recent data on the importance of Picoa spp. as desert truffles fungi. The Picoa can play a significant role in biological control agents and provide food for birds. Moreover, the decomposition of fruit-bodies of Picoa in the soils can improve the physical, chemical and biological conditions of the soils that will improve their ecological conditions.