ISSN: 0973-7510

E-ISSN: 2581-690X

K. Rupnath1 , A.L. Jayasri2, M. Rojarani3, V. Suresh4 and M. Raghuram4
1Central Tobbacco Research Institute, Rajahmundry, E.G. District, India.
2Department of Life Sciences, PNC & KR College, Palnad road, Narasaraopet, Guntur (dt), India.
3Department of Microbiology, PNC & KR College, Palnad road, Narasaraopet, Guntur (dt), India.
4Department of Biotechnology, Acharya Nagarjuna University, Guntur (India).
J Pure Appl Microbiol. 2011;5(1):377-380
© The Author(s). 2011
Received: 24/02/2011 | Accepted: 15/06/2011| Published: 30/04/2011
Abstract

Whooping cough is a severe, highly contagious respiratory disease caused by the bacterium Bordetella pertussis is an important cause of morbidity and mortality among children in many parts of world. Use of killed whole cell pertussis vaccine has been a major factor in control of symptomatic whooping cough. Immunization with whole cell vaccines (wcv’s) has significantly reduced the incidence of pertussis. However these vaccines have drawbacks in causing side effects. An attempt was made in the present work to develop non toxic acellular vaccine that can protect against disease with reduced incidence of side effects. In the present study, recombinant acellular pertussis vaccine conferred to be 80% protection in test animals in comparison to standard vaccines.

Keywords

Immunogenicity, Acellular pertussis Vaccine

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© The Author(s) 2011. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.