Whooping cough is a severe, highly contagious respiratory disease caused by the bacterium Bordetella pertussis is an important cause of morbidity and mortality among children in many parts of world. Use of killed whole cell pertussis vaccine has been a major factor in control of symptomatic whooping cough. Immunization with whole cell vaccines (wcv’s) has significantly reduced the incidence of pertussis. However these vaccines have drawbacks in causing side effects. An attempt was made in the present work to develop non toxic acellular vaccine that can protect against disease with reduced incidence of side effects. In the present study, recombinant acellular pertussis vaccine conferred to be 80% protection in test animals in comparison to standard vaccines.
Immunogenicity, Acellular pertussis Vaccine
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