ISSN: 0973-7510

E-ISSN: 2581-690X

P. Mahanta, K. Sarma , S. Das and G. Rajbongshi
1Regional Research Centre on FMD, Department of Microbiology, Assam Agricultural University, Khanapara, Guwahati, Assam – 781 022, India.
J Pure Appl Microbiol. 2013;7(1):751-758
© The Author(s). 2013
Received: 26/06/2012 | Accepted: 08/08/2012 | Published: 31/03/2013

The present study was undertaken to evaluate the immune response of cattle following simultaneous vaccination with foot and mouth disease and rabies vaccines. A binary ethylene amine BEI inactivated FMD vaccine and an inactivated rabies vaccine were used and antibody response of cattle was evaluated using a LPB ELISA and indirect ELISA. For immunization cattle were grouped into I, II, III and IV and simultaneous vaccination was carried out in Gp I. Gp II was vaccinated against FMD, Gp III against rabies separately. Gp IV was kept as unvaccinated control. On the day of vaccination, all the groups were sero-negative against FMD virus and rabies virus. The percentage of animals showing protective antibody titre against FMDV types O, A and Asia-1 at 15, 30, 60 and 90 days post vaccination were 40-30-50, 90-80-90, 90-80-80 and 80-70-70 in group I, and 60-40-50, 100-90-90, 90-80-80 and 70-70-80 in group II, respectively. The percentage of animals showing protective antibody level against rabies virus at 15, 30, 60 and 90 days post vaccination were 90, 100, 100 and 90 in group I, and 100, 100, 100 and 90 in group III, respectively. Thus the present investigation revealed that foot and mouth disease vaccine had no adverse influence on the production of antibodies against rabies vaccine. The simultaneous immunization of cattle with foot and mouth disease vaccine and rabies vaccines elicited similar antibody response against the different vaccine virus types and rabies virus, compared to antibody response of separate vaccination against FMD and rabies.


FMD virus, Rabies virus, LPB ELISA, INDIRECT ELISA

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