We investigated the antimalarial activity of the methanolic extract of Bridelia ferruginea benth bark at 400 mg/kg body weights in mice (Mus musculus) infected with chloroquine-sensitive Plasmodium berghei using the rane test. There was decreased in packed cell volume, RBC and Hb in infected groups from day zero to 14 with a corresponding increase in RBC of the uninfected -extract treated group (p<0.05). The infected – untreated showed continual decreased from day zero to 14 (p<0.05) compared to the infected – treated groups and the uninfected – untreated (control) group. However, decreased in MCHC was recorded by day 14 for the infected – untreated animals. WBC and lymphocytes indices revealed that there was no significant difference in all the groups by day zero, however by day 14, there was significant increased in the WBC and lymphocytes for infected – treated groups compared to all other groups (p<0.05). In the platelets count, by day 14 there was significant decreased in the infected – untreated group compared to others (p<0.05). Also, there was no significant difference in the neutrophils for the infected – extract treated, infected – chloroquine treated, control, and uninfected – extract treated groups (p<0.05). The haematological indices further substantiates the promising antimalarial activity of the bark extract.