Dear Editor, severe acute respiratory syndrome coronavirus 2 (SARCoV2) is a new emerging coronavirus that causes COVID-19. COVID-19 is a pandemic and attacks more than 200 countries around the world. Within 4 months, more than millions of world populations are infected. Due to the rapid spreading, an important consideration in clinical microbiology is the possible genetic variation of the new virus1. Here, the authors would like to share observations from Thailand, the second country that the COVID-19 occurs in global pandemic timeline2.
From PubMed search, there are 2 data on nucleotides of SARCoV2) isolates in Thailand (Accession: MN970004.1 and Accession: MN970003.1). The data are on “Severe acute respiratory syndrome coronavirus 2 isolate SI200121-SP orf1ab polyprotein, RdRP region, (orf1ab) gene” The 2 sequences are recorded in the same month of February 2020. From alignment by bioinformatics analysis tool LALIGN 3, there is no difference of the two sequences. This can confirm that there is no change of genetic composition of virus in our setting. This might be an explanation for the non-serous situation of COVID-19 outbreak in Thailand.
The molecular study is an important tool in surveillance of new emerging virus infection. In conclusion, no difference of studied isolate is detected. This means there is no mutation in our setting which result in no serious change of clinical features of the disease. Nevertheless, since it is not yet the end of outbreak, further closed monitoring of genetic component is recommended. The surveillance for molecular epidemiology is recommended for any country affected by COVID-19.
CONFLICT OF INTEREST
The listed author(s) declare no conflict of interest in any capacity, including competing or financial.
All listed author(s) have made a substantial, direct and intellectual contribution to the work, and approved it for publication.
- Bajaj A, Purohit HJ. Understanding SARS-CoV-2: Genetic Diversity, Transmission and Cure in Human. Indian J Microbiol. 2020:1-4.
- Yasri S, Wiwanitkit V. Editorial: Wuhan coronavirus outbreak and imported case. Adv Trop Med Pub Health Int. 2019;9:1-2.
- Biro JC, Biro JM. The BlastNP: a novel, sensitive sequence similarity searching method using overlappingly translated sequences. Conf Proc IEEE Eng Med Biol Soc. 2004;2004:2777-80.
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