Follicle-Stimulating Hormone (FSH) Activities of Some Synthesized Candidates

ISSN: 0973-7510

E-ISSN: 2581-690X

Mohamed M. Abdulla¹ , Abd El-Galil E. Amr^2,3, Nagy M. Khalifa³ and Mohamed A. Al-Omar³

¹Research Unit, Saco Pharm. Co., 6th October City 11632, Egypt.

²Applied Organic Chemistry Department, National Research Center, Dokki, Cairo, Egypt.

³Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

J Pure Appl Microbiol. 2014;8(Spl. Edn. 2):197-204

Received: 21/08/2014 | Accepted: 30/10/2014 | Published: 30/11/2014

Abstract

A series of pyridines, pyrimidinone, oxazinones, and their derivatives (1-14) were synthesized and screened as follicle-stimulating hormone (FSH) agents using abietic acid as the starting material. The pharmacological screening showed that many of these compounds have good follicle-stimulating hormone (FSH) activity comparable to Pergonal^® as reference drug. The detailed synthetic pathways of obtained compounds and Follicle-stimulating hormone (FSH) activity were reported.

Keywords

Abietic acid, Oxazinone, Pyrimidinone, Follicle-stimulating hormone (FSH) activity

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