ISSN: 0973-7510

E-ISSN: 2581-690X

Navneet Verma , A.K. Wahi, Anurag Verma, P. Chattopadhayay
College of Pharmacy, Institute of Foreign Trade and Management, Moradabad. India.
J Pure Appl Microbiol. 2007;1(1):115-118
© The Author(s). 2007
Received: 30/03/2007 | Accepted: 08/04/2007 | Published: 30/04/2007
Abstract

Mucoadhesive buccal patches of Atenolol for local delivery of the drug to the oral cavity were formulated by Solvent casting technique. Different mucoadhesive polymers, namely Polyvinyl alcohol (PVA), Sodium carboxymethyl cellulose (NaCMC) and Chitosan of different grade were incorporated into the patches to modify their mucoadhesive properties as well as the rate of drug release, using glycerol as plasticizer. Different concentrations of polymer were used for the preparation of patches. The patches were evaluated on the basis of their physical characteristics like surface pH, folding endurance, mucoadhesive performance, and release rate. The in-vitro drug release was carried out in Franz diffusion cell, with commercially available dialysis membrane. Formulation P-10 (10 % polyvinyl alcohol, 5 % glycerol and 2 % Atenolol) showed sustained release upto 18 hours and also obeyed Higuchi kinetic release pattern.

Keywords

Mucoadhesive Buccal Patch, Atenolol, Bioadhesion

Article Metrics

Article View: 1523

Share This Article

© The Author(s) 2007. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.