ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Rajendran Venkatasubramani1 and Thirumoorthy Viswanathan2
1Research and Development Centre, Bharathiar University, Coimbatore – 641 046, Tamil Nadu, India.
2Department of Microbiology, LRG Government Arts College for Women, Tirupur – 641 604, Tamil Nadu, India.
J. Pure Appl. Microbiol., 2020, 14 (1): 491-498 | Article Number: 6008 | © The Author(s). 2020
Received: 25/12/2019 | Accepted: 15/02/2020 | Published: 21/02/2020

The pathogens attained through nosocomial infection exhibit a higher degree of antibiotic resistance due to constant exposure to drug therapy. There is a need to develop alternate therapeutics for treating these resistant pathogens. Objective:  The objective of this study is to isolate pathogens from hospital-acquired infection to determine its epidemiology and multidrug resistance. In this study, urine and swab samples (354) were obtained from hospitalized patients with no prior infection history. For screening antibiotic resistance among the isolates, 15 antibiotics were used in this study, and also various piperidine compounds were used to evaluate the minimum inhibitory concentration against the isolates. Among them, 160 reported positive for the presence of Staphylococcus species (37), Salmonella species (23), Pseudomonas species (27), Proteus species (21), E. coli (34) and Klebsiella species (18). Mostly, all the pathogens obtained from clinical cases show high antibiotic resistance. The highest percentage of resistance was recorded against amoxicillin and penicillin (98%). The least rate of resistance was noticed against gentamycin (42%). Like antibiotics, the test compounds exhibited better minimum inhibitory concentration (MIC) against the test isolates. The MIC of the compounds against Staphylococcus species and E. coli was discovered to be higher when compared to Klebsiella species and Salmonella species. The piperidine compounds that were used as alternatives showed promising susceptibility towards pathogens.


Healthcare-associated infections, Nosocomial pathogens, Piperidines.

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© The Author(s) 2020. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.