ISSN: 0973-7510
E-ISSN: 2771-2780
Mesoporous silica nanoparticles (MCM-41) have an ability to increase the solubility of poorly soluble drugs. In this study, MCM-41 was synthesized. Afterward, Itraconazole (ITZ) was loaded into MCM-41 and then was wrapped by chitosan. The synthesized nanoparticles were characterized. Controlled release of ITZ from the MSNITZ and MSN-ITZ-CHI was evaluated in hydrochloride acid buffer (pH: 1.2) and phosphate buffer saline (pH: 7.4). Antifungal and cytotoxic activities of MSN-ITZ and MSN-ITZ-CHI were evaluated. Amount of loaded ITZ into MCM-41 was determined 85%. The properties of MCM-41 and loading procedure revealed high performance of the drug loading and release studies. The release profiles of MSN-ITZ were 60% in HCl medium and 40% in PBS medium. Data demonstrated more efficient and rapid release of ITZ from MSN-ITZ. Minimum inhibitory concentrations of MSN-ITZ and MSN-ITZ-CHI, on Candida albicans and Aspergillus fumigatus showed 0.25 and 0.5 µg/ml with low concentration and more inhibitory effects in comparison to the ITZ. MSN-ITZ and MSN-ITZ-CHI revealed lower toxicity in comparison to the pure drug on the cell viability of TC1 cell line (P<0.05). It could be concluded that the MSN-ITZ and MSN-ITZ-CHI nanoparticles have promising advantages for enhancing antifungal effects and drug delivery studies of itraconazole.
Aspergillus fumigatus, Candida albicans, Itraconazole, MCM-41, Mesoporous Silica Nanoparticles.
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