ISSN: 0973-7510

E-ISSN: 2581-690X

Hemant Kumar Khuntia, Surya Kanta Samal, Santanu Kumar Kar and Bibhuti Bhusan Pal
Department of Microbiology, Regional Medical Research Centre, Bhubaneswar – 751 023, India.
J Pure Appl Microbiol. 2009;3(1):371-374
© The Author(s). 2009
Received: 17/09/2008 | Accepted: 08/11/2008 | Published: 30/04/2009

This study reports the emergence of nalidixic acid resistant Vibrio cholerae O139 strains associated with diarrhoeal disorders in Orissa, India during 1999 till 2001. During 1999 to 2001, 67 V. cholerae O139 strains were isolated from the hospitalized acute diarrhea patients in Orissa. All 10 strains of O139 isolated during July 1995 to October 1999, were sensitive to nalidixic acid. The emergence of first nalidixic acid resistant V. cholerae O139 strains were observed in November 1999 and all 57 strains isolated thereafter till 2001 were resistant to nalidixic acid. Polyacrylamide gel electrophoresis of whole intracellular protein of nalidixic acid resistant V. cholerae O139 strains exhibited two extra protein bands which may be responsible for development of resistance and this should be confirmed by further analysis.


Vibrio cholerae O139, Antibiotic, Nalidixic acid, Resistance, Protein

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